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Role of capsid proteins in parvoviruses infection

Overview of attention for article published in Virology Journal, August 2015
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Title
Role of capsid proteins in parvoviruses infection
Published in
Virology Journal, August 2015
DOI 10.1186/s12985-015-0344-y
Pubmed ID
Authors

Mengyu Tu, Fei Liu, Shun Chen, Mingshu Wang, Anchun Cheng

Abstract

The parvoviruses are widely spread in many species and are among the smallest DNA animal viruses. The parvovirus is composed of a single strand molecule of DNA wrapped into an icosahedral capsid. In a viral infection, the massy capsid participates in the entire viral infection process, which is summarized in this review. The capsid protein VP1 is primarily responsible for the infectivity of the virus, and the nuclear localization signal (NLS) of the VP1 serves as a guide to assist the viral genome in locating the nucleus. The dominant protein VP2 provides an "anti-receptor", which interacts with the cellular receptor and leads to the further internalization of virus, and, the N-terminal of VP2 also cooperates with the VP1 to prompt the process of nucleus translocation. Additionally, a cleavage protein VP3 is a part of the capsid, which exists only in several members of the parvovirus family; however, the function of this cleavage protein remains to be fully determined. Parvoviruses can suffer from the extreme environmental conditions such as low pH, or even escape from the recognition of pattern recognition receptors (PRRs), due to the protection of the stable capsid, which is thought to be an immune escape mechanism. The applications of the capsid proteins to the screening and the treatment of diseases are also discussed. The processes of viral infection should be noted, because understanding the virus-host interactions will contribute to the development of therapeutic vaccines.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Lithuania 1 1%
Italy 1 1%
South Africa 1 1%
Unknown 94 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 24 25%
Student > Ph. D. Student 19 20%
Student > Master 13 13%
Student > Doctoral Student 8 8%
Researcher 8 8%
Other 13 13%
Unknown 12 12%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 24 25%
Biochemistry, Genetics and Molecular Biology 22 23%
Agricultural and Biological Sciences 18 19%
Immunology and Microbiology 6 6%
Medicine and Dentistry 5 5%
Other 9 9%
Unknown 13 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2015.
All research outputs
#12,575,443
of 19,101,906 outputs
Outputs from Virology Journal
#1,691
of 2,730 outputs
Outputs of similar age
#137,432
of 244,646 outputs
Outputs of similar age from Virology Journal
#1
of 1 outputs
Altmetric has tracked 19,101,906 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,730 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.9. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,646 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them