Title |
DART: Denoising Algorithm based on Relevance network Topology improves molecular pathway activity inference
|
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Published in |
BMC Bioinformatics, October 2011
|
DOI | 10.1186/1471-2105-12-403 |
Pubmed ID | |
Authors |
Yan Jiao, Katherine Lawler, Gargi S Patel, Arnie Purushotham, Annette F Jones, Anita Grigoriadis, Andrew Tutt, Tony Ng, Andrew E Teschendorff |
Abstract |
Inferring molecular pathway activity is an important step towards reducing the complexity of genomic data, understanding the heterogeneity in clinical outcome, and obtaining molecular correlates of cancer imaging traits. Increasingly, approaches towards pathway activity inference combine molecular profiles (e.g gene or protein expression) with independent and highly curated structural interaction data (e.g protein interaction networks) or more generally with prior knowledge pathway databases. However, it is unclear how best to use the pathway knowledge information in the context of molecular profiles of any given study. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 3% |
Germany | 1 | 1% |
Sweden | 1 | 1% |
United Kingdom | 1 | 1% |
Mexico | 1 | 1% |
Russia | 1 | 1% |
United States | 1 | 1% |
Luxembourg | 1 | 1% |
Unknown | 68 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 27 | 35% |
Student > Ph. D. Student | 17 | 22% |
Professor | 7 | 9% |
Student > Bachelor | 4 | 5% |
Professor > Associate Professor | 4 | 5% |
Other | 9 | 12% |
Unknown | 9 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 32% |
Computer Science | 13 | 17% |
Biochemistry, Genetics and Molecular Biology | 9 | 12% |
Medicine and Dentistry | 8 | 10% |
Mathematics | 4 | 5% |
Other | 8 | 10% |
Unknown | 10 | 13% |