Title |
Whipple’s disease diagnosed during anti-tumor necrosis factor alpha treatment: two case reports and review of the literature
|
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Published in |
Journal of Medical Case Reports, July 2015
|
DOI | 10.1186/s13256-015-0632-6 |
Pubmed ID | |
Authors |
Jose M. Ramos, Francisco Pasquau, Nora Galipienso, Beatriz Valero, Angela Navarro, Agustín Martinez, José Rosas, Ana Gutiérrez, Rosario Sanchez-Martínez |
Abstract |
Whipple's disease is a rare infectious disease caused by Tropheryma whippleii with protean clinical manifestations. This infection may mimic chronic inflammatory rheumatisms. We report two cases of Whipple's disease diagnosed in the context of an inflammatory disease with anti-tumor necrosis factor alpha failure. The first patient was a 58-year-old white man with psoriatic spondylarthritis, who was treated with adalimumab, etanercept, infliximab, tocilizumab and golimumab. The second was a 73-year-old white man with rheumatoid arthritis, who received treatment with infliximab, then etanercept and rituximab. Whipple's disease should be suspected in all patients diagnosed with chronic inflammatory rheumatism, partially controlled or not controlled by treatment with tumor necrosis factor alpha blockers, whose condition worsens after treatment. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
Spain | 1 | 3% |
Unknown | 32 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 8 | 24% |
Student > Ph. D. Student | 5 | 15% |
Other | 4 | 12% |
Researcher | 4 | 12% |
Student > Doctoral Student | 3 | 9% |
Other | 5 | 15% |
Unknown | 5 | 15% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 16 | 47% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Unspecified | 1 | 3% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Arts and Humanities | 1 | 3% |
Other | 4 | 12% |
Unknown | 9 | 26% |