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X Demographics
Mendeley readers
| Title |
Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress
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|---|---|
| Published in |
BMC Biology, June 2018
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| DOI | 10.1186/s12915-018-0525-4 |
| Pubmed ID | |
| Authors |
Florian A. Britto, Fabienne Cortade, Yassine Belloum, Marine Blaquière, Yann S. Gallot, Aurélie Docquier, Allan F. Pagano, Elodie Jublanc, Nadia Bendridi, Christelle Koechlin-Ramonatxo, Béatrice Chabi, Marc Francaux, François Casas, Damien Freyssenet, Jennifer Rieusset, Sophie Giorgetti-Peraldi, Gilles Carnac, Vincent Ollendorff, François B. Favier |
| Abstract |
Skeletal muscle atrophy is a common feature of numerous chronic pathologies and is correlated with patient mortality. The REDD1 protein is currently recognized as a negative regulator of muscle mass through inhibition of the Akt/mTORC1 signaling pathway. REDD1 expression is notably induced following glucocorticoid secretion, which is a component of energy stress responses. Unexpectedly, we show here that REDD1 instead limits muscle loss during energetic stresses such as hypoxia and fasting by reducing glycogen depletion and AMPK activation. Indeed, we demonstrate that REDD1 is required to decrease O2 and ATP consumption in skeletal muscle via reduction of the extent of mitochondrial-associated endoplasmic reticulum membranes (MAMs), a central hub connecting energy production by mitochondria and anabolic processes. In fact, REDD1 inhibits ATP-demanding processes such as glycogen storage and protein synthesis through disruption of the Akt/Hexokinase II and PRAS40/mTORC1 signaling pathways in MAMs. Our results uncover a new REDD1-dependent mechanism coupling mitochondrial respiration and anabolic processes during hypoxia, fasting, and exercise. Therefore, REDD1 is a crucial negative regulator of energy expenditure that is necessary for muscle adaptation during energetic stresses. This present study could shed new light on the role of REDD1 in several pathologies associated with energetic metabolism alteration, such as cancer, diabetes, and Parkinson's disease. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 8% |
| United States | 1 | 8% |
| United Kingdom | 1 | 8% |
| Mexico | 1 | 8% |
| Unknown | 9 | 69% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 62% |
| Scientists | 3 | 23% |
| Science communicators (journalists, bloggers, editors) | 2 | 15% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 65 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 17% |
| Student > Ph. D. Student | 9 | 14% |
| Student > Bachelor | 7 | 11% |
| Researcher | 7 | 11% |
| Student > Doctoral Student | 3 | 5% |
| Other | 5 | 8% |
| Unknown | 23 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 18% |
| Agricultural and Biological Sciences | 8 | 12% |
| Medicine and Dentistry | 4 | 6% |
| Sports and Recreations | 4 | 6% |
| Nursing and Health Professions | 3 | 5% |
| Other | 10 | 15% |
| Unknown | 24 | 37% |