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Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV)

Overview of attention for article published in Respiratory Research, June 2018
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  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Average Attention Score compared to outputs of the same age and source

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32 Mendeley
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Title
Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV)
Published in
Respiratory Research, June 2018
DOI 10.1186/s12931-018-0821-0
Pubmed ID
Authors

Stella Xu, Emily A. Vucic, Tawimas Shaipanich, Stephen Lam, Wan Lam, Julio S. Montaner, Don D. Sin, S. F. Paul Man, Janice M. Leung

Abstract

Human immunodeficiency virus (HIV) infection is associated with an increased risk of chronic obstructive pulmonary disease (COPD) independent of cigarette smoke exposure. Previous studies have demonstrated that decreased peripheral leukocyte telomere length is associated with HIV, suggesting an accelerated aging phenomenon. We demonstrate that this process of telomere shortening also occurs in the lungs, with significant decreases in telomere length observed in small airway epithelial cells collected during bronchoscopy. Molecular evidence of accelerated aging in the small airway epithelium of persons living with HIV may be one clue into the predisposition for chronic lung disease observed in this population.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 22%
Researcher 5 16%
Student > Bachelor 4 13%
Other 2 6%
Student > Doctoral Student 2 6%
Other 2 6%
Unknown 10 31%
Readers by discipline Count As %
Medicine and Dentistry 9 28%
Biochemistry, Genetics and Molecular Biology 3 9%
Business, Management and Accounting 1 3%
Nursing and Health Professions 1 3%
Arts and Humanities 1 3%
Other 4 13%
Unknown 13 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2018.
All research outputs
#8,538,940
of 25,382,440 outputs
Outputs from Respiratory Research
#1,153
of 3,062 outputs
Outputs of similar age
#137,170
of 341,533 outputs
Outputs of similar age from Respiratory Research
#35
of 67 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,533 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.