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X Demographics
Mendeley readers
| Title |
Carcinogenic effects of circadian disruption: an epigenetic viewpoint
|
|---|---|
| Published in |
Cancer Communications, August 2015
|
| DOI | 10.1186/s40880-015-0043-5 |
| Pubmed ID | |
| Authors |
Adrian Salavaty |
| Abstract |
Circadian rhythms refer to the endogenous rhythms that are generated to synchronize physiology and behavior with 24-h environmental cues. These rhythms are regulated by both external cues and molecular clock mechanisms in almost all cells. Disruption of circadian rhythms, which is called circadian disruption, affects many biological processes within the body and results in different long-term diseases, including cancer. Circadian regulatory pathways result in rhythmic epigenetic modifications and the formation of circadian epigenomes. Aberrant epigenetic modifications, such as hypermethylation, due to circadian disruption may be involved in the transformation of normal cells into cancer cells. Several studies have indicated an epigenetic basis for the carcinogenic effects of circadian disruption. In this review, I first discuss some of the circadian genes and regulatory proteins. Then, I summarize the current evidence related to the epigenetic modifications that result in circadian disruption. In addition, I explain the carcinogenic effects of circadian disruption and highlight its potential role in different human cancers using an epigenetic viewpoint. Finally, the importance of chronotherapy in cancer treatment is highlighted. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 33% |
| Australia | 2 | 11% |
| Ireland | 1 | 6% |
| Spain | 1 | 6% |
| Japan | 1 | 6% |
| Unknown | 7 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 72% |
| Practitioners (doctors, other healthcare professionals) | 3 | 17% |
| Scientists | 1 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | 1% |
| United States | 1 | 1% |
| Portugal | 1 | 1% |
| Sweden | 1 | 1% |
| Unknown | 67 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 15% |
| Researcher | 11 | 15% |
| Student > Bachelor | 8 | 11% |
| Student > Master | 7 | 10% |
| Student > Postgraduate | 5 | 7% |
| Other | 15 | 21% |
| Unknown | 14 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 21% |
| Medicine and Dentistry | 13 | 18% |
| Biochemistry, Genetics and Molecular Biology | 11 | 15% |
| Environmental Science | 3 | 4% |
| Psychology | 2 | 3% |
| Other | 11 | 15% |
| Unknown | 16 | 23% |