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Carcinogenic effects of circadian disruption: an epigenetic viewpoint

Overview of attention for article published in Ai zheng Aizheng Chinese journal of cancer, August 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#12 of 231)
  • High Attention Score compared to outputs of the same age (88th percentile)

Mentioned by

twitter
18 tweeters
facebook
7 Facebook pages

Citations

dimensions_citation
16 Dimensions

Readers on

mendeley
63 Mendeley
citeulike
1 CiteULike
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Title
Carcinogenic effects of circadian disruption: an epigenetic viewpoint
Published in
Ai zheng Aizheng Chinese journal of cancer, August 2015
DOI 10.1186/s40880-015-0043-5
Pubmed ID
Authors

Abbas Salavaty

Abstract

Circadian rhythms refer to the endogenous rhythms that are generated to synchronize physiology and behavior with 24-h environmental cues. These rhythms are regulated by both external cues and molecular clock mechanisms in almost all cells. Disruption of circadian rhythms, which is called circadian disruption, affects many biological processes within the body and results in different long-term diseases, including cancer. Circadian regulatory pathways result in rhythmic epigenetic modifications and the formation of circadian epigenomes. Aberrant epigenetic modifications, such as hypermethylation, due to circadian disruption may be involved in the transformation of normal cells into cancer cells. Several studies have indicated an epigenetic basis for the carcinogenic effects of circadian disruption. In this review, I first discuss some of the circadian genes and regulatory proteins. Then, I summarize the current evidence related to the epigenetic modifications that result in circadian disruption. In addition, I explain the carcinogenic effects of circadian disruption and highlight its potential role in different human cancers using an epigenetic viewpoint. Finally, the importance of chronotherapy in cancer treatment is highlighted.

Twitter Demographics

The data shown below were collected from the profiles of 18 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 2%
United States 1 2%
Portugal 1 2%
Sweden 1 2%
Unknown 59 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 19%
Researcher 11 17%
Student > Master 7 11%
Student > Bachelor 7 11%
Student > Postgraduate 4 6%
Other 12 19%
Unknown 10 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 24%
Medicine and Dentistry 11 17%
Biochemistry, Genetics and Molecular Biology 10 16%
Environmental Science 4 6%
Psychology 2 3%
Other 9 14%
Unknown 12 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2018.
All research outputs
#1,577,706
of 16,581,438 outputs
Outputs from Ai zheng Aizheng Chinese journal of cancer
#12
of 231 outputs
Outputs of similar age
#27,347
of 237,709 outputs
Outputs of similar age from Ai zheng Aizheng Chinese journal of cancer
#1
of 1 outputs
Altmetric has tracked 16,581,438 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 231 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,709 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them