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Attention Score in Context
| Title |
Role of hormonal and inflammatory alterations in obesity-related reproductive dysfunction at the level of the hypothalamic-pituitary-ovarian axis
|
|---|---|
| Published in |
Reproductive Biology and Endocrinology, May 2018
|
| DOI | 10.1186/s12958-018-0366-6 |
| Pubmed ID | |
| Authors |
Michelle Goldsammler, Zaher Merhi, Erkan Buyuk |
| Abstract |
Besides being a risk factor for multiple metabolic disorders, obesity could affect female reproduction. While increased adiposity is associated with hormonal changes that could disrupt the function of the hypothalamus and the pituitary, compelling data suggest that obesity-related hormonal and inflammatory changes could directly impact ovarian function. To review the available data related to the mechanisms by which obesity, and its associated hormonal and inflammatory changes, could affect the female reproductive function with a focus on the hypothalamic-pituitary-ovarian (HPO) axis. PubMed database search for publications in English language until October 2017 pertaining to obesity and female reproductive function was performed. The obesity-related changes in hormone levels, in particular leptin, adiponectin, ghrelin, neuropeptide Y and agouti-related protein, are associated with reproductive dysfunction at both the hypothalamic-pituitary and the ovarian levels. The pro-inflammatory molecules advanced glycation end products (AGEs) and monocyte chemotactic protein-1 (MCP-1) are emerging as relatively new players in the pathophysiology of obesity-related ovarian dysfunction. There is an intricate crosstalk between the adipose tissue and the inflammatory system with the HPO axis function. Understanding the mechanisms behind this crosstalk could lead to potential therapies for the common obesity-related reproductive dysfunction. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 163 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 163 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 25 | 15% |
| Student > Master | 21 | 13% |
| Student > Ph. D. Student | 16 | 10% |
| Researcher | 8 | 5% |
| Lecturer | 6 | 4% |
| Other | 25 | 15% |
| Unknown | 62 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 33 | 20% |
| Biochemistry, Genetics and Molecular Biology | 19 | 12% |
| Agricultural and Biological Sciences | 13 | 8% |
| Nursing and Health Professions | 8 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Other | 17 | 10% |
| Unknown | 66 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2018.
All research outputs
#17,980,413
of 23,090,520 outputs
Outputs from Reproductive Biology and Endocrinology
#630
of 991 outputs
Outputs of similar age
#237,437
of 327,494 outputs
Outputs of similar age from Reproductive Biology and Endocrinology
#13
of 21 outputs
Altmetric has tracked 23,090,520 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 991 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.0. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,494 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.