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“Velcro-type” crackles predict specific radiologic features of fibrotic interstitial lung disease

Overview of attention for article published in BMC Pulmonary Medicine, June 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

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Title
“Velcro-type” crackles predict specific radiologic features of fibrotic interstitial lung disease
Published in
BMC Pulmonary Medicine, June 2018
DOI 10.1186/s12890-018-0670-0
Pubmed ID
Authors

Giacomo Sgalla, Simon L. F. Walsh, Nicola Sverzellati, Sophie Fletcher, Stefania Cerri, Borislav Dimitrov, Dragana Nikolic, Anna Barney, Fabrizio Pancaldi, Luca Larcher, Fabrizio Luppi, Mark G. Jones, Donna Davies, Luca Richeldi

Abstract

"Velcro-type" crackles on chest auscultation are considered a typical acoustic finding of Fibrotic Interstitial Lung Disease (FILD), however whether they may have a role in the early detection of these disorders has been unknown. This study investigated how "Velcro-type" crackles correlate with the presence of distinct patterns of FILD and individual radiologic features of pulmonary fibrosis on High Resolution Computed Tomography (HRCT). Lung sounds were digitally recorded from subjects immediately prior to undergoing clinically indicated chest HRCT. Audio files were independently assessed by two chest physicians and both full volume and single HRCT sections corresponding to the recording sites were extracted. The relationships between audible "Velcro-type" crackles and radiologic HRCT patterns and individual features of pulmonary fibrosis were investigated using multivariate regression models. 148 subjects were enrolled: bilateral "Velcro-type" crackles predicted the presence of FILD at HRCT (OR 13.46, 95% CI 5.85-30.96, p < 0.001) and most strongly the Usual Interstitial Pneumonia (UIP) pattern (OR 19.8, 95% CI 5.28-74.25, p < 0.001). Extent of isolated reticulation (OR 2.04, 95% CI 1.62-2.57, p < 0.001), honeycombing (OR 1.88, 95% CI 1.24-2.83, < 0.01), ground glass opacities (OR 1.74, 95% CI 1.29-2.32, p < 0.001) and traction bronchiectasis (OR 1.55, 95% CI 1.03-2.32, p < 0.05) were all independently associated with the presence of "Velcro-type" crackles. "Velcro-type" crackles predict the presence of FILD and directly correlate with the extent of distinct radiologic features of pulmonary fibrosis. Such evidence provides grounds for further investigation of lung sounds as an early identification tool in FILD.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 61 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 16%
Student > Bachelor 6 10%
Student > Postgraduate 6 10%
Other 5 8%
Student > Master 5 8%
Other 5 8%
Unknown 24 39%
Readers by discipline Count As %
Medicine and Dentistry 21 34%
Engineering 5 8%
Computer Science 2 3%
Neuroscience 2 3%
Immunology and Microbiology 1 2%
Other 2 3%
Unknown 28 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2023.
All research outputs
#2,334,522
of 24,616,908 outputs
Outputs from BMC Pulmonary Medicine
#126
of 2,140 outputs
Outputs of similar age
#47,371
of 333,538 outputs
Outputs of similar age from BMC Pulmonary Medicine
#5
of 53 outputs
Altmetric has tracked 24,616,908 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,140 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,538 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.