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Mendeley readers
| Title |
Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay
|
|---|---|
| Published in |
BMC Biology, May 2009
|
| DOI | 10.1186/1741-7007-7-23 |
| Pubmed ID | |
| Authors |
Zhenguo Zhang, Dedong Xin, Ping Wang, Li Zhou, Landian Hu, Xiangyin Kong, Laurence D Hurst |
| Abstract |
Nonsense-mediated decay is a mechanism that degrades mRNAs with a premature termination codon. That some exons have premature termination codons at fixation is paradoxical: why make a transcript if it is only to be destroyed? One model supposes that splicing is inherently noisy and spurious transcripts are common. The evolution of a premature termination codon in a regularly made unwanted transcript can be a means to prevent costly translation. Alternatively, nonsense-mediated decay can be regulated under certain conditions so the presence of a premature termination codon can be a means to up-regulate transcripts needed when nonsense-mediated decay is suppressed. |
Mendeley readers
The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| Colombia | 1 | <1% |
| Uganda | 1 | <1% |
| Germany | 1 | <1% |
| France | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 96 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 33% |
| Researcher | 29 | 28% |
| Student > Bachelor | 7 | 7% |
| Student > Master | 6 | 6% |
| Student > Doctoral Student | 5 | 5% |
| Other | 10 | 10% |
| Unknown | 13 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 51 | 49% |
| Biochemistry, Genetics and Molecular Biology | 27 | 26% |
| Medicine and Dentistry | 5 | 5% |
| Computer Science | 2 | 2% |
| Linguistics | 1 | <1% |
| Other | 4 | 4% |
| Unknown | 14 | 13% |