↓ Skip to main content

Boron delivery agents for neutron capture therapy of cancer

Overview of attention for article published in Cancer Communications, June 2018
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#7 of 174)
  • High Attention Score compared to outputs of the same age (84th percentile)

Mentioned by

blogs
1 blog
twitter
3 tweeters
wikipedia
1 Wikipedia page
googleplus
1 Google+ user

Citations

dimensions_citation
195 Dimensions

Readers on

mendeley
236 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Boron delivery agents for neutron capture therapy of cancer
Published in
Cancer Communications, June 2018
DOI 10.1186/s40880-018-0299-7
Pubmed ID
Authors

Rolf F. Barth, Peng Mi, Weilian Yang

Abstract

Boron neutron capture therapy (BNCT) is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope, boron-10, is irradiated with neutrons to produce high energy alpha particles. This review will focus on tumor-targeting boron delivery agents that are an essential component of this binary system. Two low molecular weight boron-containing drugs currently are being used clinically, boronophenylalanine (BPA) and sodium borocaptate (BSH). Although they are far from being ideal, their therapeutic efficacy has been demonstrated in patients with high grade gliomas, recurrent tumors of the head and neck region, and a much smaller number with cutaneous and extra-cutaneous melanomas. Because of their limitations, great effort has been expended over the past 40 years to develop new boron delivery agents that have more favorable biodistribution and uptake for clinical use. These include boron-containing porphyrins, amino acids, polyamines, nucleosides, peptides, monoclonal antibodies, liposomes, nanoparticles of various types, boron cluster compounds and co-polymers. Currently, however, none of these have reached the stage where there is enough convincing data to warrant clinical biodistribution studies. Therefore, at present the best way to further improve the clinical efficacy of BNCT would be to optimize the dosing paradigms and delivery of BPA and BSH, either alone or in combination, with the hope that future research will identify new and better boron delivery agents for clinical use.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 236 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 236 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 37 16%
Student > Bachelor 33 14%
Student > Ph. D. Student 32 14%
Student > Master 28 12%
Student > Doctoral Student 10 4%
Other 30 13%
Unknown 66 28%
Readers by discipline Count As %
Chemistry 57 24%
Biochemistry, Genetics and Molecular Biology 20 8%
Medicine and Dentistry 16 7%
Engineering 16 7%
Physics and Astronomy 12 5%
Other 31 13%
Unknown 84 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2020.
All research outputs
#1,878,819
of 18,672,358 outputs
Outputs from Cancer Communications
#7
of 174 outputs
Outputs of similar age
#45,263
of 287,727 outputs
Outputs of similar age from Cancer Communications
#1
of 1 outputs
Altmetric has tracked 18,672,358 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 174 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,727 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them