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Activity of Porophyllum ruderale leaf extract and 670-nm InGaP laser during burns repair in rats

Overview of attention for article published in BMC Complementary Medicine and Therapies, August 2015
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Title
Activity of Porophyllum ruderale leaf extract and 670-nm InGaP laser during burns repair in rats
Published in
BMC Complementary Medicine and Therapies, August 2015
DOI 10.1186/s12906-015-0805-2
Pubmed ID
Authors

Ana Cristina Justino Jácomo, Karina de Andrade Velozo, Raquel Gabilan Lotti, Lia Mara Grosso Neves, Fernanda Oliveira de Gaspari de Gaspi, Marcelo A. Marreto Esquisatto, Maria Esméria Corezola do Amaral, Fernanda A. Sampaio Mendonça, Gláucia Maria Tech dos Santos

Abstract

In this study, we investigated the effects of an extract of the leaves of Porophyllum ruderale and laser irradiation on the healing of burns. Seventy-two rats were divided in four groups: untreated controls, treated with laser irradiation, treated with P. ruderale and treated with both P. ruderale and laser irradiation. Burns were produced with a metal plate on the backs of the animals. Wound samples were collected for structural and morphometric analyses and to quantify the expression of TGF-β1 and VEGF. Laser irradiation increased the number of fibroblasts, collagen fibers and newly formed vessels and decreased the number of granulocytes at the site of the wounds. Densitometric analysis revealed a significant increase in the expression of TGFβ-1 in the wounds treated with laser irradiation and with the P. ruderale extract at the beginning of the healing process and a decreased during the experimental period. The expression of VEGF was highlighted in the lesions irradiated with laser alone. Inspite of not showing a beneficial effect on the laser combination with the P. ruderale extract, when the laser was used separately, a positive effects to enhance the healing of second-degree burns was promoted. P. ruderale was effective in decreasing the granulocytes during the repair process indicating a possible anti-inflammatory action of this extract of native flora, widely used in folk medicine, but little studied experimentally.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Unknown 39 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 13%
Other 4 10%
Student > Doctoral Student 3 8%
Student > Ph. D. Student 3 8%
Student > Postgraduate 2 5%
Other 6 15%
Unknown 17 43%
Readers by discipline Count As %
Medicine and Dentistry 6 15%
Biochemistry, Genetics and Molecular Biology 5 13%
Nursing and Health Professions 2 5%
Chemistry 2 5%
Business, Management and Accounting 1 3%
Other 5 13%
Unknown 19 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2015.
All research outputs
#15,342,608
of 22,821,814 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,043
of 3,631 outputs
Outputs of similar age
#154,980
of 264,395 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#52
of 93 outputs
Altmetric has tracked 22,821,814 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,631 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,395 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.