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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co-infection
|
|---|---|
| Published in |
Malaria Journal, August 2015
|
| DOI | 10.1186/s12936-015-0835-8 |
| Pubmed ID | |
| Authors |
Vitor R R Mendonça, Bruno B Andrade, Ligia C L Souza, Belisa M L Magalhães, Maria P G Mourão, Marcus V G Lacerda, Manoel Barral-Netto |
| Abstract |
Concurrent malaria and dengue infection is frequently diagnosed in endemic countries, but its immunopathology remains largely unknown. In the present study, a large panel of cytokines/chemokines and clinical laboratory markers were measured in patients with Plasmodium vivax and dengue co-infection as well as in individuals with malaria or dengue mono-infections in order to identify biosignatures of each clinical condition. Individuals from the Brazilian Amazon were recruited between 2009 and 2013 and classified in three groups: vivax malaria (n = 52), dengue (n = 30) and vivax malaria and dengue co-infection (n = 30). P. vivax malaria was diagnosed by thick blood smear and confirmed by PCR; dengue cases were detected by IgM ELISA or NS1 protein. The plasma levels of cytokines and chemokines were determined by multiplex assay. Individuals with malaria and dengue co-infection displayed lower levels of platelets and haemoglobin than those with malaria or dengue mono-infections (p = 0.0047 and p = 0.0001, respectively). The group of individuals co-infected exhibited the highest median concentrations of IFN-γ, IL-6, CCL4 than the mono-infected groups. Network analyses of plasma cytokines/chemokines revealed that malaria and dengue co-infection exhibits a distinct immune profile with critical roles for TNF, IL-6 and IFN-γ. Further, parasitaemia levels displayed positive significant interactions with IL-6, CCL4 and IL-10 in the group of patients co-infected with malaria and dengue. No differences were observed in distribution of dengue virus serotypes and Plasmodium parasitaemia levels between the groups. The findings described here identify unique patterns of circulating immunological markers in cases of malaria and dengue co-infection and provide insights on the immunopathology of this co-morbid condition. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Cameroon | 1 | 14% |
| Nigeria | 1 | 14% |
| Unknown | 5 | 71% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 57% |
| Scientists | 2 | 29% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | 3% |
| Spain | 1 | 1% |
| Unknown | 94 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 19% |
| Researcher | 16 | 16% |
| Student > Bachelor | 16 | 16% |
| Student > Ph. D. Student | 7 | 7% |
| Student > Postgraduate | 5 | 5% |
| Other | 12 | 12% |
| Unknown | 23 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 28% |
| Agricultural and Biological Sciences | 15 | 15% |
| Immunology and Microbiology | 14 | 14% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Other | 7 | 7% |
| Unknown | 25 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2017.
All research outputs
#2,433,630
of 24,400,706 outputs
Outputs from Malaria Journal
#510
of 5,827 outputs
Outputs of similar age
#31,484
of 268,976 outputs
Outputs of similar age from Malaria Journal
#10
of 112 outputs
Altmetric has tracked 24,400,706 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,827 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,976 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.