Title |
Translating clinical trials from human to veterinary oncology and back
|
---|---|
Published in |
Journal of Translational Medicine, August 2015
|
DOI | 10.1186/s12967-015-0631-9 |
Pubmed ID | |
Authors |
Irene Fürdös, Judit Fazekas, Josef Singer, Erika Jensen-Jarolim |
Abstract |
In human medicine clinical trials are legally required for drug development and approval. In contrast, clinical trials in small animal cancer patients are less common and legally perceived as animal experiments. Comparative oncology has been recognized as a method to speed up the development of medications by introducing animal patients with naturally developing tumours. In such cases, using animal patients would generate more robust data, as their spontaneous disease resembles the "real life" situation and thus could be more likely to predict the situation in human disease. This would not only provide veterinary oncology access to the latest developments in medicine before they are available for clinical use in animals, but could also lead to generation of clinical data in animal patients that could be translated to humans. Nevertheless, there are several limitations to practical conduct of clinical trials in veterinary medicine. In this review, the possible application of similar standards of Good Clinical Practice as in human clinical drug development will be discussed in detail, with special consideration of legal and ethical aspects in Europe and the US. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 38% |
Spain | 1 | 13% |
South Africa | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 88% |
Scientists | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | 2% |
Unknown | 52 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 15% |
Student > Master | 8 | 15% |
Student > Doctoral Student | 6 | 11% |
Student > Ph. D. Student | 5 | 9% |
Student > Bachelor | 4 | 8% |
Other | 10 | 19% |
Unknown | 12 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 11 | 21% |
Medicine and Dentistry | 9 | 17% |
Agricultural and Biological Sciences | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 7 | 13% |
Unknown | 14 | 26% |