Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency. https://t.co/3Xvp6F7BIP
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RT @BluefieldProj: (3/3) The Roberson Lab @UAB_Alzheimers reported that partial (50%) reduction of TMEM106B failed to rescue behavioral an…
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RT @BluefieldProj: (3/3) The Roberson Lab @UAB_Alzheimers reported that partial (50%) reduction of TMEM106B failed to rescue behavioral an…
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(3/3) The Roberson Lab @UAB_Alzheimers reported that partial (50%) reduction of TMEM106B failed to rescue behavioral and most lysosomal abnormalities in Grn+/- mice. TMEM106B SNPs must modulate FTD risk in #progranulin mutation carriers another way. https