Title |
sRAGE in diabetic and non-diabetic critically ill patients: effects of intensive insulin therapy
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Published in |
Critical Care, August 2011
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DOI | 10.1186/cc10420 |
Pubmed ID | |
Authors |
Yaseen M Arabi, Mohammed Dehbi, Asgar H Rishu, Engin Baturcam, Salim H Kahoul, Riette J Brits, Brintha Naidu, Abderrezak Bouchama |
Abstract |
Hyperglycemia represents an independent prognostic factor in critically ill non-diabetic patients but not in those with diabetes. In this context, there is an ongoing debate on the benefit of an intensive insulin therapy, particularly in diabetic patients. We tested the hypothesis that expression of the receptor for advanced glycation end-products (RAGE), an important signal transduction receptor that elicits long-lasting nuclear factor kappa B (NF-κB) activation, may underlie this difference. RAGE expression is regulated by multiple ligands, including high mobility group box-1 (HMGB-1), and is reflected by its released soluble form (sRAGE). |
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Researcher | 8 | 13% |
Other | 8 | 13% |
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Unknown | 15 | 25% |
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