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A new instrument for estimation of survival in elderly patients irradiated for metastatic spinal cord compression from breast cancer

Overview of attention for article published in Radiation Oncology, August 2015
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Title
A new instrument for estimation of survival in elderly patients irradiated for metastatic spinal cord compression from breast cancer
Published in
Radiation Oncology, August 2015
DOI 10.1186/s13014-015-0483-8
Pubmed ID
Authors

Dirk Rades, Antonio J. Conde, Raquel Garcia, Jon Cacicedo, Barbara Segedin, Ana Perpar, Steven E. Schild

Abstract

Elderly patients become more important in oncology. In this group, personalized treatment approaches taking into account survival prognoses and comorbidities play a major role. Predictive instruments are necessary to estimate the survival of elderly cancer patients. The importance of separate instruments for different tumor entities has been recognized. In this study, an instrument was generated to estimate the survival of elderly patients developing metastatic spinal cord compression (MSCC) from breast cancer. In 218 elderly patients (age ≥65 years) irradiated for MSCC from breast cancer, nine factors were evaluated for survival: fractionation regimen, age, time from breast cancer diagnosis to RT of MSCC, visceral metastases, other bone metastases, time developing motor deficits, pre-radiotherapy ambulatory status, number of involved vertebrae, and Eastern Cooperative Oncology Group (ECOG) performance score. Factors significantly associated with survival in the Cox regression analysis were included in the prognostic instrument. Scores for each factor were calculated by dividing the 6-months survival rates by 10. The sums of these scores represented the patients' scores. On multivariate analyses, visceral metastases (p < 0.001), time developing motor deficits (p < 0.001), ambulatory status (p < 0.001), number of involved vertebrae (p = 0.032), and ECOG performance score (p < 0.001) were significant and included in the prognostic instrument. Based on the patients' scores, three groups were designed: 18-27 points, 28-39 points and 40-42 points. Six-months survival rates were 4, 62 and 100 %, respectively (p < 0.001). This new instrument contributes to personalized treatment in elderly patients with MSCC from breast cancer by predicting an individual patient's survival prognosis.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 24%
Other 4 12%
Student > Ph. D. Student 4 12%
Student > Master 4 12%
Professor > Associate Professor 3 9%
Other 6 18%
Unknown 4 12%
Readers by discipline Count As %
Medicine and Dentistry 21 64%
Biochemistry, Genetics and Molecular Biology 2 6%
Neuroscience 2 6%
Sports and Recreations 2 6%
Nursing and Health Professions 1 3%
Other 1 3%
Unknown 4 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2015.
All research outputs
#13,953,851
of 22,824,164 outputs
Outputs from Radiation Oncology
#749
of 2,056 outputs
Outputs of similar age
#132,792
of 266,176 outputs
Outputs of similar age from Radiation Oncology
#30
of 69 outputs
Altmetric has tracked 22,824,164 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,056 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,176 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.