Title |
Interleukin-32: its role in asthma and potential as a therapeutic agent
|
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Published in |
Respiratory Research, June 2018
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DOI | 10.1186/s12931-018-0832-x |
Pubmed ID | |
Authors |
Tong Xin, Mo Chen, Liwei Duan, Yanling Xu, Peng Gao |
Abstract |
Interleukin (IL)-32, also named natural killer cell transcript 4 (NK4), has increasingly been described as an immunoregulator that controls cell differentiation and cell death and is involved in the stimulation of anti-/pro-inflammatory cytokines. Abnormal presence of IL-32 has been repeatedly noticed during the pathogenesis of allergic, infectious, cancerous, and inflammatory diseases. Of particular note was the observation of the anti-inflammatory property of IL-32 in a murine ovalbumin model of allergic asthma. Compared to wild-type mice, IL-32γ transgenic mice show decreased levels of inflammatory cells, recruited eosinophils, and lymphocytes in bronchoalveolar lavage fluid in a mouse model of acute asthma. To date, the molecular mechanism underlying the role of IL-32 in asthma remains to be elucidated. This review aims to summarize recent advances in the pathophysiology of asthma and describe the links to IL-32. The possibilities of using IL-32 as an airway inflammation biomarker and an asthma therapeutic agent are also evaluated. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 14% |
Mexico | 1 | 14% |
Canada | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 71% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Scientists | 1 | 14% |
Mendeley readers
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Researcher | 6 | 21% |
Student > Doctoral Student | 3 | 11% |
Student > Bachelor | 3 | 11% |
Student > Postgraduate | 2 | 7% |
Student > Master | 2 | 7% |
Other | 3 | 11% |
Unknown | 9 | 32% |
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Medicine and Dentistry | 5 | 18% |
Nursing and Health Professions | 3 | 11% |
Immunology and Microbiology | 2 | 7% |
Sports and Recreations | 1 | 4% |
Other | 0 | 0% |
Unknown | 11 | 39% |