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Disposition of cimicoxib in plasma and milk of whelping bitches and in their puppies

Overview of attention for article published in BMC Veterinary Research, July 2015
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Title
Disposition of cimicoxib in plasma and milk of whelping bitches and in their puppies
Published in
BMC Veterinary Research, July 2015
DOI 10.1186/s12917-015-0496-4
Pubmed ID
Authors

M. Schneider, A. Kuchta, F. Dron, F. Woehrlé

Abstract

Caesarean section of bitches is a well recognized painful condition in dogs and it can be classified as a soft tissue surgery. Cimicoxib, a newly registered NSAID in European Union has a claim for the relief of pain in peri-operative conditions. However, in case of caesarean section, the main concerns of using NSAIDs are the transfer of the drugs into milk and its impact on the suckling pups. Thus, the aim of the present work was to evaluate the transfer of cimicoxib into the milk of 6 lactating bitches after a single oral administration of the drug on day 0 (just after whelping) and on day 28 at the target dose of 2 mg/kg. Another aim of the study was to evaluate the transfer of the drug from the milk into the suckling pups. Blood and milk samples were collected from the bitches after each administration on day 0 and day 28 and blood samples were drawn from the pups after suckling on day 28. All bitches whelped without any complication and gave birth to 38 pups. After administration on D0, the mean observed plasma Cmax in bitches was 0.5323 μg/mL and the mean area under the concentration-time curve extrapolated to the infinity, AUCINF, was 2.411 μg.h/mL. After administration on D28, only AUCINF was significantly higher with a value of 3.747 μg.h/mL. In milk, after administration on D0, the mean observed Cmax was 0.9974 μg/mL and the mean area under the concentration-time curve until the last measurable time point, AUClast, was 4.205 μg.h/mL. Out of 24 sampled pups on D28, only 2 animals had a sample with very low cimicoxib concentrations slightly above the limit of quantification (0.01 μg/mL). The presented data show that cimicoxib given by oral route to lactating bitches at a single dose of 2 mg/kg had a high transfer rate into the milk with a milk to plasma ratio of 1.7 to 1.9. The transfer rate to the suckling pups was low and no clinical abnormalities were detected in both bitches and pups.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 18%
Unspecified 2 9%
Student > Ph. D. Student 2 9%
Professor 2 9%
Student > Postgraduate 2 9%
Other 3 14%
Unknown 7 32%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 9 41%
Unspecified 2 9%
Biochemistry, Genetics and Molecular Biology 1 5%
Nursing and Health Professions 1 5%
Agricultural and Biological Sciences 1 5%
Other 1 5%
Unknown 7 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2015.
All research outputs
#20,288,585
of 22,824,164 outputs
Outputs from BMC Veterinary Research
#2,417
of 3,050 outputs
Outputs of similar age
#219,635
of 262,905 outputs
Outputs of similar age from BMC Veterinary Research
#59
of 72 outputs
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So far Altmetric has tracked 3,050 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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