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The role of epidermal sphingolipids in dermatologic diseases

Overview of attention for article published in Lipids in Health and Disease, January 2016
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Mentioned by

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Citations

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49 Dimensions

Readers on

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74 Mendeley
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Title
The role of epidermal sphingolipids in dermatologic diseases
Published in
Lipids in Health and Disease, January 2016
DOI 10.1186/s12944-016-0178-7
Pubmed ID
Authors

Sonia Borodzicz, Lidia Rudnicka, Dagmara Mirowska-Guzel, Agnieszka Cudnoch-Jedrzejewska

Abstract

Sphingolipids, a group of lipids containing the sphingoid base, have both structural and biological functions in human epidermis. Ceramides, as a part of extracellular lipids in the stratum corneum, are important elements of the skin barrier and are involved in the prevention of transepidermal water loss. In addition, ceramides regulate such processes as proliferation, differentiation and apoptosis of keratinocytes. Another important sphingolipid, sphingosine-1-phosphate (S1P), inhibits proliferation and induces differentiation of keratinocytes. A recent clinical study of the efficacy and safety of ponesimod (a selective modulator of the S1P receptor 1) suggested that sphingolipid metabolism may become a new target for the pharmacological treatment of psoriasis. The role of sphingolipids in some dermatologic diseases, including psoriasis, atopic dermatitis and ichthyoses was summarized in this article.

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 74 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 18%
Student > Master 13 18%
Researcher 11 15%
Student > Postgraduate 6 8%
Student > Doctoral Student 5 7%
Other 12 16%
Unknown 14 19%
Readers by discipline Count As %
Medicine and Dentistry 15 20%
Biochemistry, Genetics and Molecular Biology 11 15%
Agricultural and Biological Sciences 8 11%
Chemistry 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 7%
Other 10 14%
Unknown 19 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2018.
All research outputs
#8,223,307
of 13,116,247 outputs
Outputs from Lipids in Health and Disease
#481
of 950 outputs
Outputs of similar age
#160,070
of 268,702 outputs
Outputs of similar age from Lipids in Health and Disease
#1
of 1 outputs
Altmetric has tracked 13,116,247 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 950 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,702 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them