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Lost in folding space? Comparing four variants of the thermodynamic model for RNA secondary structure prediction

Overview of attention for article published in BMC Bioinformatics, November 2011
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74 Mendeley
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Title
Lost in folding space? Comparing four variants of the thermodynamic model for RNA secondary structure prediction
Published in
BMC Bioinformatics, November 2011
DOI 10.1186/1471-2105-12-429
Pubmed ID
Authors

Stefan Janssen, Christian Schudoma, Gerhard Steger, Robert Giegerich

Abstract

Many bioinformatics tools for RNA secondary structure analysis are based on a thermodynamic model of RNA folding. They predict a single, "optimal" structure by free energy minimization, they enumerate near-optimal structures, they compute base pair probabilities and dot plots, representative structures of different abstract shapes, or Boltzmann probabilities of structures and shapes. Although all programs refer to the same physical model, they implement it with considerable variation for different tasks, and little is known about the effects of heuristic assumptions and model simplifications used by the programs on the outcome of the analysis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Canada 2 3%
Turkey 2 3%
France 2 3%
Brazil 2 3%
Colombia 1 1%
Germany 1 1%
United Kingdom 1 1%
Denmark 1 1%
Other 1 1%
Unknown 59 80%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 24%
Researcher 18 24%
Professor > Associate Professor 8 11%
Student > Doctoral Student 7 9%
Student > Master 7 9%
Other 11 15%
Unknown 5 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 43 58%
Biochemistry, Genetics and Molecular Biology 9 12%
Computer Science 6 8%
Mathematics 2 3%
Physics and Astronomy 2 3%
Other 7 9%
Unknown 5 7%