@ScienceScottT @anshulkundaje @KasperDHansen It's an interesting thought, and there's some evidence. Greater CpG island length (which is of course directly related to hypomethylated region width) is associated with lower cell-to-cell expression variability
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@rosa2003 looks like something of your interest!
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'An intriguing possibility has been recently raised by single-cell expression measurements showing that promoter CpG islands are associated with reduced expression variability (Morgan, Marioni, 2018).' Morgan, Marioni, 2018: https://t.co/iuVGHgj3Ih
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CpG island composition differences are a source of gene expression noise indicative of promoter responsiveness. https://t.co/ch6HMAPdhS