Title |
Serum markers of CYFRA 21-1 and C-reactive proteins in oral squamous cell carcinoma
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Published in |
World Journal of Surgical Oncology, August 2015
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DOI | 10.1186/s12957-015-0656-9 |
Pubmed ID | |
Authors |
Yin-Ping Hsu, Chia-Hsun Hsieh, Hui-Tzu Chien, Chi-Hsiung Lai, Chung-Kan Tsao, Chun-Ta Liao, Chung-Jan Kang, Hung-Ming Wang, Joseph Tung-Chieh Chang, Shiang-Fu Huang |
Abstract |
CYFRA 21-1 (cytokeratin 19 fragment) and C-reactive proteins (CRP) were separately reported to be associated with prognosis of head and neck squamous cell carcinoma. The combined roles of CYFRA 21-1 and CRP levels were rarely investigated in oral squamous cell carcinoma (OSCC). The purpose of the present study was to analyze the relationship between preoperative levels of both CYFRA 21-1 and CRP, with clinicopathological factors and prognosis in OSCC patients. A retrospective study was performed on 130 OSCC patients between December 2010 and June 2013. Their serum CYFRA 21-1 and CRP levels were measured preoperatively. CYFRA 21-1 level of ≥3.3 ng/mL and CRP level of ≥5.0 mg/L were significantly associated with pathological tumor status (P < 0.001), tumor depth (>10 vs. ≤10 mm, P = 0.001), bone invasion (P = 0.001), skin invasion (P = 0.006), pathologic nodal metastasis (P = 0.012), and disease-free survival (P = 0.009). Higher CYPFRA 21-1 and CRP levels were also associated with higher risks of distant metastasis (log-rank test, P = 0.013, (HR [95 % CI]) 1.692 [1.097-2.414]). Preoperative CYFRA 21-1 and CRP levels are probable candidates as biomarkers for risk stratification in OSCC. |
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Student > Bachelor | 4 | 11% |
Unspecified | 3 | 8% |
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Student > Doctoral Student | 2 | 5% |
Other | 8 | 22% |
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Other | 3 | 8% |
Unknown | 11 | 30% |