Title |
Recombinant E2 protein enhances protective efficacy of inactivated bovine viral diarrhea virus 2 vaccine in a goat model
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Published in |
BMC Veterinary Research, June 2018
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DOI | 10.1186/s12917-018-1520-2 |
Pubmed ID | |
Authors |
Yao-Chi Chung, Li-Ting Cheng, Jia-Yu Zhang, Yue-Jyun Wu, Shyh-Shyan Liu, Chun-Yen Chu |
Abstract |
Inactivated and subunit bovine viral diarrhea virus (BVDV) vaccines have shown limited protective efficacy. This study aimed to evaluate the effectiveness of a vaccine containing both inactivated BVDV (iBVDV) and baculovirus-expressed recombinant E2 (rE2), an important BVDV antigen with strongly neutralizing epitopes. Four groups of goats were immunized twice with one of four vaccine preparations: 1) iBVDV+rE2, 2) rE2, 3) iBVDV, and 4) saline, and challenged with BVDV. For goats vaccinated with the iBVDV+rE2 vaccine, no viremia was observed after challenge, and clinical signs, pyrexia, and leukopenia were reduced compared to the saline group. In contrast, for goats vaccinated with either iBVDV or rE2 alone, viremia was still detectable. The combination of iBVDV and rE2 elicited stronger protective immune responses against BVDV than iBVDV or rE2 alone. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 19% |
Student > Master | 3 | 12% |
Student > Ph. D. Student | 3 | 12% |
Student > Doctoral Student | 2 | 8% |
Professor > Associate Professor | 2 | 8% |
Other | 2 | 8% |
Unknown | 9 | 35% |
Readers by discipline | Count | As % |
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Veterinary Science and Veterinary Medicine | 5 | 19% |
Biochemistry, Genetics and Molecular Biology | 3 | 12% |
Agricultural and Biological Sciences | 2 | 8% |
Immunology and Microbiology | 2 | 8% |
Chemistry | 1 | 4% |
Other | 0 | 0% |
Unknown | 13 | 50% |