Title |
Plasmablastic lymphoma in Malawi
|
---|---|
Published in |
Infectious Agents and Cancer, June 2018
|
DOI | 10.1186/s13027-018-0195-4 |
Pubmed ID | |
Authors |
Takondwa Zuze, Matthew S. Painschab, Ryan Seguin, Evarista Kudowa, Bongani Kaimila, Edwards Kasonkanji, Tamiwe Tomoka, Bal Mukunda Dhungel, Maurice Mulenga, Maria Chikasema, Blessings Tewete, Asekanadziwa Ntangwanika, Sarah Chiyoyola, Fred Chimzimu, Coxcilly Kampani, Robert Krysiak, Nathan D. Montgomery, Yuri Fedoriw, Satish Gopal |
Abstract |
Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26-71), seven (58%) were male, and six (50%) were HIV-positive. Eight patients were treated with CHOP and four with a modified EPOCH regimen. One-year overall survival was 56% (95% CI 24-79%), without clear differences based on HIV status. PBL occurs in Malawi in HIV-positive and HIV-negative individuals and can be treated successfully with curative intent, even in a low-resource setting in SSA. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 3 | 12% |
Student > Postgraduate | 3 | 12% |
Researcher | 3 | 12% |
Librarian | 1 | 4% |
Student > Bachelor | 1 | 4% |
Other | 3 | 12% |
Unknown | 12 | 46% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 50% |
Nursing and Health Professions | 1 | 4% |
Unspecified | 1 | 4% |
Unknown | 11 | 42% |