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Urinary iodine excretion and thyroid function status in school age children of hilly and plain regions of Eastern Nepal

Overview of attention for article published in BMC Research Notes, August 2015
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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Title
Urinary iodine excretion and thyroid function status in school age children of hilly and plain regions of Eastern Nepal
Published in
BMC Research Notes, August 2015
DOI 10.1186/s13104-015-1359-6
Pubmed ID
Authors

Prem Raj Shakya, Basanta Gelal, Binod Kumar Lal Das, Madhab Lamsal, Paras Kumar Pokharel, Ashwini Kumar Nepal, David A. Brodie, Gauri Shankar Sah, Nirmal Baral

Abstract

Iodine deficiency is a major public health problem in many developing countries including Nepal. The present study was designed to investigate the urinary iodine excretion (UIE), thyroid function status and household salt iodine content (SIC) in school-aged children (SAC) and to establish the relationships between these factors. A community-based cross sectional study was conducted in selected schools of two districts, Tehrathum and Morang, lying in the hill and plain region of eastern Nepal respectively. A total of 640 SAC, (Tehrathum n = 274 and Morang n = 366) aged 6-11 years, were assessed for UIE and household SIC. Among the 640 children, 155 consented to blood samples (Tehrathum n = 78 and Morang n = 77) to test for serum thyroglobulin (Tg), thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4). UIE was measured by ammonium persulfate digestion method. SIC was measured by iodometric titration method and Tg, TSH, fT4 and fT3 were measured by immunoassay based kit method. In Tehrathum and Morang, 9.5 and 7.7 % of SAC had UIE values of UIE <100 µg/L while 59.5 and 41 % had iodine nutrition values of >299 µg/L, with median UIE of 345.65 and 270.36 µg/L respectively. The overall medians were as follows, Tg 14.29 µg/L, fT3 3.94 pmol/L, fT4 16.25 pmol/L and TSH 3.61 mIU/L. There was a negative correlation between UIE and Tg (r = -0.236, p = 0.003) and a positive correlation between UIE and SIC (r = 0.349, p < 0.0001). We found 19.5 %, n = 15 and 16.7 %, n = 13 subclinical hypothyroid cases in Morang and Tehrathum respectively. Iodometric titration showed only 6.4% (n = 41) of the samples had household SIC <15 ppm. Multivariate analysis revealed that use of packaged salt by SAC of Tehrathum district correlated with higher UIE values. Our focused data suggests that collaborative universal salt iodization (USI) programs are improving the health of children in the Tehrathum and Morang districts of Nepal. We also found that excessive iodine in a large portion of the study groups is a substantial concern and iodine intervention programs need to deal with both deficient and excessive iodine scenarios that can both be present simultaneously in study populations.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Nepal 1 2%
Unknown 43 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 18%
Researcher 5 11%
Student > Ph. D. Student 4 9%
Student > Bachelor 4 9%
Student > Postgraduate 3 7%
Other 8 18%
Unknown 12 27%
Readers by discipline Count As %
Medicine and Dentistry 10 23%
Nursing and Health Professions 6 14%
Agricultural and Biological Sciences 5 11%
Psychology 3 7%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 4 9%
Unknown 15 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2015.
All research outputs
#2,553,635
of 5,526,446 outputs
Outputs from BMC Research Notes
#694
of 1,744 outputs
Outputs of similar age
#87,018
of 194,206 outputs
Outputs of similar age from BMC Research Notes
#45
of 135 outputs
Altmetric has tracked 5,526,446 research outputs across all sources so far. This one has received more attention than most of these and is in the 51st percentile.
So far Altmetric has tracked 1,744 research outputs from this source. They receive a mean Attention Score of 4.1. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,206 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.