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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis
|
|---|---|
| Published in |
BMC Research Notes, June 2018
|
| DOI | 10.1186/s13104-018-3526-z |
| Pubmed ID | |
| Authors |
Sheo B. Singh, Joshua Odingo, Mai A. Bailey, Bjorn Sunde, Aaron Korkegian, Theresa O’Malley, Yulia Ovechkina, Thomas R. Ioerger, James C. Sacchettini, Katherine Young, David B. Olsen, Tanya Parish |
| Abstract |
Our aim was to identify natural products with anti-tubercular activity. A set of ~ 500 purified natural product compounds was screened for inhibition against the human pathogen Mycobacterium tuberculosis. A series of cyclic hexapeptides with anti-tubercular activity was identified. Five analogs from a set of sixteen closely related compounds were active, with minimum inhibitory concentrations ranging from 2.3 to 8.9 μM. Eleven structural analogs had no significant activity (MIC > 20 μM) demonstrating structure activity relationship. Sequencing of resistant mutant isolates failed to identify changes accounting for the resistance phenotype. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 57% |
| United Kingdom | 1 | 14% |
| Unknown | 2 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Scientists | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 12 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 17% |
| Student > Bachelor | 1 | 8% |
| Student > Master | 1 | 8% |
| Researcher | 1 | 8% |
| Professor > Associate Professor | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 5 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 25% |
| Immunology and Microbiology | 2 | 17% |
| Chemistry | 1 | 8% |
| Medicine and Dentistry | 1 | 8% |
| Unknown | 5 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2019.
All research outputs
#6,373,202
of 23,092,602 outputs
Outputs from BMC Research Notes
#967
of 4,287 outputs
Outputs of similar age
#110,920
of 329,253 outputs
Outputs of similar age from BMC Research Notes
#26
of 137 outputs
Altmetric has tracked 23,092,602 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 4,287 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,253 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 137 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.