Title |
Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis
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Published in |
Journal of Negative Results in BioMedicine, November 2011
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DOI | 10.1186/1477-5751-10-14 |
Pubmed ID | |
Authors |
Raquel M Scarel-Caminaga, Karen MC Curtis, Rivelto Renzi, Patrícia M Sogumo, Giovana Anovazzi, Aline C Viana, Yeon J Kim, Silvana RP Orrico, Joni A Cirelli |
Abstract |
The chemokine receptor 1 CXCR-1 (or IL8R-alpha) is a specific receptor for the interleukin 8 (IL-8), which is chemoattractant for neutrophils and has an important role in the inflammatory response. The polymorphism rs2234671 at position Ex2+860G>C of the CXCR1 gene causes a conservative amino acid substitution (S276T). This single nucleotide polymorphism (SNP) seemed to be functional as it was associated with decreased lung cancer risk. Previous studies of our group found association of haplotypes in the IL8 and in the CXCR2 genes with the multifactorial disease chronic periodontitis. In this study we investigated the polymorphism rs2234671 in 395 Brazilian subjects with and without chronic periodontitis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 22% |
Student > Master | 4 | 17% |
Student > Postgraduate | 4 | 17% |
Student > Bachelor | 3 | 13% |
Student > Doctoral Student | 2 | 9% |
Other | 4 | 17% |
Unknown | 1 | 4% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 65% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Arts and Humanities | 1 | 4% |
Agricultural and Biological Sciences | 1 | 4% |
Unspecified | 1 | 4% |
Other | 2 | 9% |
Unknown | 1 | 4% |