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CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease

Overview of attention for article published in Journal of Neuroinflammation, November 2011
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  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

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Title
CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease
Published in
Journal of Neuroinflammation, November 2011
DOI 10.1186/1742-2094-8-154
Pubmed ID
Authors

Shi Zhang, Xi-Jin Wang, Li-Peng Tian, Jing Pan, Guo-Qiang Lu, Ying-Jie Zhang, Jian-Qing Ding, Sheng-Di Chen

Abstract

Increasing evidence suggests that microglial activation may participate in the aetiology and pathogenesis of Parkinson's disease (PD). CD200-CD200R signalling has been shown to be critical for restraining microglial activation. We have previously shown that expression of CD200R in monocyte-derived macrophages, induced by various stimuli, is impaired in PD patients, implying an intrinsic abnormality of CD200-CD200R signalling in PD brain. Thus, further in vivo evidence is needed to elucidate the role of malfunction of CD200-CD200R signalling in the pathogenesis of PD.

X Demographics

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 <1%
Australia 1 <1%
Unknown 122 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 23%
Student > Bachelor 24 19%
Researcher 14 11%
Student > Master 9 7%
Professor 7 6%
Other 18 15%
Unknown 23 19%
Readers by discipline Count As %
Neuroscience 28 23%
Agricultural and Biological Sciences 28 23%
Medicine and Dentistry 17 14%
Biochemistry, Genetics and Molecular Biology 16 13%
Chemistry 3 2%
Other 8 6%
Unknown 24 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2011.
All research outputs
#13,357,126
of 22,656,971 outputs
Outputs from Journal of Neuroinflammation
#1,429
of 2,601 outputs
Outputs of similar age
#86,374
of 141,898 outputs
Outputs of similar age from Journal of Neuroinflammation
#10
of 21 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,601 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 141,898 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.