Title |
Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study
|
---|---|
Published in |
Arthritis Research & Therapy, November 2011
|
DOI | 10.1186/ar3510 |
Pubmed ID | |
Authors |
Linda van Wyk, Jacolien van der Marel, Annemie JM Schuerwegh, Anne A Schouffoer, Alexandre E Voskuyl, Tom WJ Huizinga, Diana W Bianchi, Sicco A Scherjon |
Abstract |
Studies have shown that fetal progenitor cells persist in maternal blood or bone marrow for more than 30 years after delivery. Increased trafficking of fetal cells occurs during pregnancy complications, such as hypertension, preeclampsia, miscarriage and intra-uterine growth restriction (IUGR). Women with these pregnancy complications are significantly more often HLA-class II compatible with their spouses. Women who later develop scleroderma also give birth to an HLA-class II child more often. From these prior studies we hypothesized that preeclampsia and other pregnancy complications could be associated with increased levels of fetal cell trafficking, and later be involved in the development of scleroderma. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Canada | 1 | 3% |
Unknown | 38 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 9 | 23% |
Researcher | 9 | 23% |
Student > Master | 5 | 13% |
Student > Ph. D. Student | 4 | 10% |
Other | 4 | 10% |
Other | 5 | 13% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 53% |
Nursing and Health Professions | 4 | 10% |
Agricultural and Biological Sciences | 4 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Social Sciences | 2 | 5% |
Other | 1 | 3% |
Unknown | 6 | 15% |