You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Genomic characterization of colitis-associated colorectal cancer
|
|---|---|
| Published in |
World Journal of Surgical Oncology, July 2018
|
| DOI | 10.1186/s12957-018-1428-0 |
| Pubmed ID | |
| Authors |
Hitoshi Kameyama, Masayuki Nagahashi, Yoshifumi Shimada, Yosuke Tajima, Hiroshi Ichikawa, Masato Nakano, Jun Sakata, Takashi Kobayashi, Sumana Narayanan, Kazuaki Takabe, Toshifumi Wakai |
| Abstract |
Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), is a chronic, idiopathic, repeated inflammatory disease. Colorectal cancer (CRC) that develops in patients with IBD is known as colitis-associated colorectal cancer (CAC), but the underlying carcinogenic mechanism remains unclear. Genomic analysis of sporadic CRC has been well described based on next-generation sequencing (NGS) data. Using NGS, we compared all exons of 415 cancer-associated genes in patients in Japan and the USA who had CRC and found similar genomic alteration patterns among the two populations. However, genomic analysis of CAC has not been thoroughly investigated. The molecular pathogenesis of CAC shares many features with sporadic CRC, but there are distinct variations in the time and frequency of some alterations. Gene alterations in CAC are gradually being elucidated using genomic sequencing analyses. Some studies have shown that gene alteration patterns differ between UC and CD. The carcinogenesis of CAC depends on unique environmental, genetic, and immunological factors. In this review, we have discussed the differences in genomic alterations between sporadic CRC and CAC. NGS in patients with IBD has the potential to detect early CAC and to suggest therapeutic targets. |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 107 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 14% |
| Student > Master | 13 | 12% |
| Student > Ph. D. Student | 12 | 11% |
| Student > Bachelor | 11 | 10% |
| Student > Doctoral Student | 6 | 6% |
| Other | 15 | 14% |
| Unknown | 35 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 29% |
| Biochemistry, Genetics and Molecular Biology | 16 | 15% |
| Agricultural and Biological Sciences | 6 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Nursing and Health Professions | 2 | 2% |
| Other | 8 | 7% |
| Unknown | 39 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2018.
All research outputs
#20,525,274
of 23,094,276 outputs
Outputs from World Journal of Surgical Oncology
#1,595
of 2,065 outputs
Outputs of similar age
#287,394
of 327,941 outputs
Outputs of similar age from World Journal of Surgical Oncology
#17
of 24 outputs
Altmetric has tracked 23,094,276 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,065 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,941 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.