Title |
RimabotulinumtoxinB in sialorrhea: systematic review of clinical trials
|
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Published in |
Journal of Clinical Movement Disorders, June 2017
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DOI | 10.1186/s40734-017-0055-1 |
Pubmed ID | |
Authors |
Khashayar Dashtipour, Roongroj Bhidayasiri, Jack J. Chen, Bahman Jabbari, Mark Lew, Diego Torres-Russotto |
Abstract |
The aim of this study was to examine the efficacy, safety and dosing practices of rimabotulinumtoxinB (BoNT-B) for the treatment of patients with sialorrhea based on a systematic review of clinical trials. A systematic literature review was performed to identify randomized controlled trials and other comparative clinical studies of BoNT-B for the treatment of sialorrhea published in English between January 1999 and December 2015. Medical literature databases (PubMed, Cochrane Library, and EMBASE) were searched and a total of 41 records were identified. Of these, six primary publications that evaluated BoNT-B for the treatment of sialorrhea met criteria and were included in the final data report. Total BoNT-B doses ranged from 1500 to 4000 units for sialorrhea. Most of the studies in sialorrhea showed statistically significant benefits of BoNT-B versus placebo (range 4-19.2 weeks). BoNT-B was generally well tolerated across the individual studies; most adverse events reported were considered unrelated to treatment. Adverse events considered potentially associated with BoNT-B included: dry mouth, change in saliva thickness, mild transient dysphagia, mild weakness of chewing and diarrhea. BoNT-B significantly reduces sialorrhea at doses between 1500 and 4000 units. The relatively mild dose-dependent adverse events suggest both direct and remote toxin effects. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 20% |
Other | 6 | 13% |
Student > Bachelor | 5 | 11% |
Student > Ph. D. Student | 5 | 11% |
Researcher | 4 | 9% |
Other | 5 | 11% |
Unknown | 12 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 26% |
Nursing and Health Professions | 7 | 15% |
Agricultural and Biological Sciences | 6 | 13% |
Neuroscience | 2 | 4% |
Psychology | 1 | 2% |
Other | 3 | 7% |
Unknown | 15 | 33% |