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Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells

Overview of attention for article published in Veterinary Research, July 2018
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63 Mendeley
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Title
Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells
Published in
Veterinary Research, July 2018
DOI 10.1186/s13567-018-0551-9
Pubmed ID
Authors

Artur Szczepanski, Katarzyna Owczarek, Aleksandra Milewska, Zbigniew Baster, Zenon Rajfur, Judy A. Mitchell, Krzysztof Pyrc

Abstract

Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus. Here, we examined entry of CRCoV into human rectal tumor cells (HRT-18G cell line) by analyzing co-localization of single virus particles with cellular markers in the presence or absence of chemical inhibitors of pathways potentially involved in virus entry. We also targeted these pathways using siRNA. The results show that the virus hijacks caveolin-dependent endocytosis to enter cells via endocytic internalization.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 63 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 22%
Student > Ph. D. Student 9 14%
Student > Bachelor 8 13%
Other 5 8%
Student > Postgraduate 4 6%
Other 10 16%
Unknown 13 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 19%
Medicine and Dentistry 7 11%
Agricultural and Biological Sciences 7 11%
Veterinary Science and Veterinary Medicine 4 6%
Immunology and Microbiology 4 6%
Other 12 19%
Unknown 17 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2020.
All research outputs
#14,605,790
of 25,385,509 outputs
Outputs from Veterinary Research
#613
of 1,337 outputs
Outputs of similar age
#171,234
of 341,301 outputs
Outputs of similar age from Veterinary Research
#21
of 34 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,337 research outputs from this source. They receive a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,301 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.