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An Interferon Signature in the Peripheral Blood of Dermatomyositis Patients is Associated with Disease Activity

Overview of attention for article published in Molecular Medicine, January 2007
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)

Mentioned by

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4 patents
wikipedia
1 Wikipedia page

Citations

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229 Dimensions

Readers on

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77 Mendeley
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Title
An Interferon Signature in the Peripheral Blood of Dermatomyositis Patients is Associated with Disease Activity
Published in
Molecular Medicine, January 2007
DOI 10.2119/2006-00085.baechler
Pubmed ID
Authors

Emily C. Baechler, Jason W. Bauer, Catherine A. Slattery, Ward A. Ortmann, Karl J. Espe, Jill Novitzke, Steven R. Ytterberg, Peter K. Gregersen, Timothy W. Behrens, Ann M. Reed

Abstract

Recent studies have shown increased expression of interferon (IFN)-regulated genes in the peripheral blood cells of patients with systemic lupus erythematosus. A similar interferon signature has been observed in affected muscle tissue from patients with dermatomyositis (DM), but it has not yet been determined if this signature extends to the peripheral blood in DM. We performed global gene expression profiling of peripheral blood cells from adult and juvenile DM patients and healthy controls. Several interesting groups of genes were differentially expressed in DM, including genes with immune function, and others that function in muscle or are involved in mitochondrial/oxidative phosphorylation. Investigation of type I IFN-regulated transcripts revealed a striking interferon signature present in most DM patients studied. Levels of type I IFN-regulated proteins were also elevated in DM serum samples. Furthermore, both the transcript and serum protein IFN signatures were associated with disease activity. These data suggest that the IFN signature may be a useful marker for DM disease activity, and that sampling peripheral blood may be a more practical alternative to muscle biopsy for measuring this signature.

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
Netherlands 2 3%
Germany 1 1%
Unknown 72 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 25%
Student > Ph. D. Student 15 19%
Student > Bachelor 6 8%
Student > Doctoral Student 5 6%
Student > Postgraduate 5 6%
Other 15 19%
Unknown 12 16%
Readers by discipline Count As %
Medicine and Dentistry 28 36%
Agricultural and Biological Sciences 20 26%
Biochemistry, Genetics and Molecular Biology 6 8%
Immunology and Microbiology 4 5%
Neuroscience 4 5%
Other 2 3%
Unknown 13 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2021.
All research outputs
#2,945,766
of 20,918,346 outputs
Outputs from Molecular Medicine
#101
of 1,043 outputs
Outputs of similar age
#42,249
of 251,820 outputs
Outputs of similar age from Molecular Medicine
#1
of 1 outputs
Altmetric has tracked 20,918,346 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,043 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,820 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them