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In vivo rescue of alveolar macrophages from SP-A knockout mice with exogenous SP-A nearly restores a wild type intracellular proteome; actin involvement

Overview of attention for article published in Proteome Science, October 2011
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Title
In vivo rescue of alveolar macrophages from SP-A knockout mice with exogenous SP-A nearly restores a wild type intracellular proteome; actin involvement
Published in
Proteome Science, October 2011
DOI 10.1186/1477-5956-9-67
Pubmed ID
Authors

David S Phelps, Todd M Umstead, Omar A Quintero, Christopher M Yengo, Joanna Floros

Abstract

Mice lacking surfactant protein-A (SP-A-/-; knockout; KO) exhibit increased vulnerability to infection and injury. Although many bronchoalveolar lavage (BAL) protein differences between KO and wild-type (WT) are rapidly reversed in KO after infection, their clinical course is still compromised. We studied the impact of SP-A on the alveolar macrophage (AM) proteome under basal conditions. Male SP-A KO mice were SP-A-treated (5 micrograms/mouse) and sacrificed in 6 or 18 hr. The AM proteomes of KO, SP-A-treated KO, and WT mice were studied by 2D-DIGE coupled with MALDI-ToF/ToF and AM actin distribution was examined by phalloidon staining.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 5%
France 1 5%
Unknown 20 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 36%
Student > Master 3 14%
Professor 2 9%
Professor > Associate Professor 2 9%
Other 1 5%
Other 2 9%
Unknown 4 18%
Readers by discipline Count As %
Medicine and Dentistry 6 27%
Agricultural and Biological Sciences 5 23%
Biochemistry, Genetics and Molecular Biology 2 9%
Unspecified 1 5%
Mathematics 1 5%
Other 2 9%
Unknown 5 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2011.
All research outputs
#14,721,336
of 22,656,971 outputs
Outputs from Proteome Science
#93
of 188 outputs
Outputs of similar age
#93,551
of 140,785 outputs
Outputs of similar age from Proteome Science
#5
of 5 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 188 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,785 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.