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Bisphosphonates as anticancer agents in early breast cancer: preclinical and clinical evidence

Overview of attention for article published in Breast Cancer Research, September 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

twitter
5 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
27 Dimensions

Readers on

mendeley
51 Mendeley
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Title
Bisphosphonates as anticancer agents in early breast cancer: preclinical and clinical evidence
Published in
Breast Cancer Research, September 2015
DOI 10.1186/s13058-015-0634-8
Pubmed ID
Authors

Daniele Santini, Luciano Stumbo, Chiara Spoto, Loretta D’Onofrio, Francesco Pantano, Michele Iuliani, Marco fioramonti, Alice Zoccoli, Giulia Ribelli, Vladimir Virzì, Bruno Vincenzi, Giuseppe Tonini

Abstract

Bisphosphonates (BPs) are approved as standard therapy in breast cancer for the treatment of bone metastases, since they were demonstrated to reduce the prevalence of skeletal-related events including fractures and hypercalcemia. In the adjuvant setting, BPs can be given to prevent and treat tumor therapy-induced bone loss in premenopausal and postmenopausal women and, owing to their beneficial effect on bone turnover, have also been evaluated for prevention of bone metastases occurrence. In this article we will review the mechanisms through which BPs have been demonstrated to prevent premetastatic niche formation and cell proliferation in bone lesions. Moreover, preclinical evidence of antitumoral effects of BPs will be presented and results from the most important clinical trials will be described critically. BPs may clearly play a clinically important role in early breast cancer in a postmenopausal adjuvant setting.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 50 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 22%
Student > Ph. D. Student 9 18%
Student > Doctoral Student 6 12%
Professor 4 8%
Student > Postgraduate 4 8%
Other 9 18%
Unknown 8 16%
Readers by discipline Count As %
Medicine and Dentistry 13 25%
Agricultural and Biological Sciences 7 14%
Chemistry 7 14%
Biochemistry, Genetics and Molecular Biology 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Other 5 10%
Unknown 12 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2016.
All research outputs
#6,747,425
of 20,957,071 outputs
Outputs from Breast Cancer Research
#830
of 1,838 outputs
Outputs of similar age
#83,845
of 252,989 outputs
Outputs of similar age from Breast Cancer Research
#3
of 13 outputs
Altmetric has tracked 20,957,071 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,838 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,989 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.