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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Targeting molecular resistance in castration-resistant prostate cancer
|
|---|---|
| Published in |
BMC Medicine, September 2015
|
| DOI | 10.1186/s12916-015-0457-6 |
| Pubmed ID | |
| Authors |
Thenappan Chandrasekar, Joy C. Yang, Allen C. Gao, Christopher P. Evans |
| Abstract |
Multiple mechanisms of resistance contribute to the inevitable progression of hormone-sensitive prostate cancer to castration-resistant prostate cancer (CRPC). Currently approved therapies for CRPC include systemic chemotherapy (docetaxel and cabazitaxel) and agents targeting the resistance pathways leading to CRPC, including enzalutamide and abiraterone. While there is significant survival benefit, primary and secondary resistance to these therapies develops rapidly. Up to one-third of patients have primary resistance to enzalutamide and abiraterone; the remaining patients eventually progress on treatment. Understanding the mechanisms of resistance resulting in progression as well as identifying new targetable pathways remains the focus of current prostate cancer research. We review current knowledge of mechanisms of resistance to the currently approved treatments, development of adjunctive therapies, and identification of new pathways being targeted for therapeutic purposes. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 87 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 17% |
| Researcher | 13 | 15% |
| Student > Bachelor | 13 | 15% |
| Student > Master | 11 | 13% |
| Student > Postgraduate | 5 | 6% |
| Other | 11 | 13% |
| Unknown | 20 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 28% |
| Biochemistry, Genetics and Molecular Biology | 17 | 19% |
| Agricultural and Biological Sciences | 10 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
| Nursing and Health Professions | 1 | 1% |
| Other | 2 | 2% |
| Unknown | 27 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2016.
All research outputs
#6,424,790
of 22,826,360 outputs
Outputs from BMC Medicine
#2,416
of 3,430 outputs
Outputs of similar age
#75,938
of 266,863 outputs
Outputs of similar age from BMC Medicine
#87
of 103 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 3,430 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.5. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,863 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.