Title |
Electrically stimulated cell migration and its contribution to wound healing
|
---|---|
Published in |
Burns & Trauma, July 2018
|
DOI | 10.1186/s41038-018-0123-2 |
Pubmed ID | |
Authors |
Guangping Tai, Michael Tai, Min Zhao |
Abstract |
Naturally occurring electric fields are known to be morphogenetic cues and associated with growth and healing throughout mammalian and amphibian animals and the plant kingdom. Electricity in animals was discovered in the eighteenth century. Electric fields activate multiple cellular signaling pathways such as PI3K/PTEN, the membrane channel of KCNJ15/Kir4.2 and intracellular polyamines. These pathways are involved in the sensing of physiological electric fields, directional cell migration (galvanotaxis, also known as electrotaxis), and possibly other cellular responses. Importantly, electric fields provide a dominant and over-riding signal that directs cell migration. Electrical stimulation could be a promising therapeutic method in promoting wound healing and activating regeneration of chronic and non-healing wounds. This review provides an update of the physiological role of electric fields, its cellular and molecular mechanisms, its potential therapeutic value, and questions that still await answers. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 20% |
United States | 1 | 20% |
China | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 199 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 39 | 20% |
Student > Master | 27 | 14% |
Researcher | 21 | 11% |
Student > Bachelor | 17 | 9% |
Student > Doctoral Student | 14 | 7% |
Other | 26 | 13% |
Unknown | 55 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 32 | 16% |
Biochemistry, Genetics and Molecular Biology | 23 | 12% |
Materials Science | 17 | 9% |
Medicine and Dentistry | 13 | 7% |
Agricultural and Biological Sciences | 12 | 6% |
Other | 36 | 18% |
Unknown | 66 | 33% |