Title |
Thoracic injection of low-dose interleukin-2 as an adjuvant therapy improves the control of the malignant pleural effusions: a systematic review and meta-analysis base on Chinese patients
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Published in |
BMC Cancer, July 2018
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DOI | 10.1186/s12885-018-4581-5 |
Pubmed ID | |
Authors |
Liping Han, Qiufang Jiang, Wei Yao, Tian Fu, Qingdi Zeng |
Abstract |
Interleukin-2 (IL-2) is an important immunotherapy cytokine for various diseases including cancer. Some studies reported the efficacy and safety on cisplatin combined with IL-2 versus cisplatin alone for treating malignant pleural effusion (MPE) through thoracic injection. We searched these studies from medical electronic database. A total of 18 studies that met the inclusion criteria were recruited in this meta-analysis. Pooled odds ratios (OR) with 95% confidence intervals (CI) were determined by the fixed effects model of meta-analysis. The objective response rate (ORR) and disease control rate (DCR) of cisplatin plus IL-2 for controlling MPE was significantly higher than that of cisplatin alone (p < 0.001). In addition, compared with cisplatin alone, the presence of IL-2 improved the quality of life (QOL) of patients with MPE (p < 0.001). Although the use of IL-2 seemed to increase the probability of fever in patients (p = 0.001), it did not lead to extra other side effects (AEs) including myelotoxicity, nausea/vomiting and chest pain (p > 0.05). The low-dose IL-2 improved the ORR, DCR and QOL of patients in the treatment of MPE. Although it may cause fever in patients, it did not increase other AEs. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 7 | 24% |
Student > Ph. D. Student | 5 | 17% |
Student > Bachelor | 2 | 7% |
Other | 2 | 7% |
Researcher | 2 | 7% |
Other | 5 | 17% |
Unknown | 6 | 21% |
Readers by discipline | Count | As % |
---|---|---|
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Nursing and Health Professions | 3 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Psychology | 1 | 3% |
Other | 3 | 10% |
Unknown | 5 | 17% |