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Temporal clustering of neuroblastic tumours in children and young adults from Northern England

Overview of attention for article published in Environmental Health, September 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

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Title
Temporal clustering of neuroblastic tumours in children and young adults from Northern England
Published in
Environmental Health, September 2015
DOI 10.1186/s12940-015-0058-z
Pubmed ID
Authors

Colin R. Muirhead, Deborah A. Tweddle, Nermine O. Basta, Richard J. Q. McNally

Abstract

The aetiology of neuroblastic tumours is unclear with both genetic and environmental factors implicated. The possibility that an infectious agent may be involved has been suggested. 'Temporal clustering' occurs if cases display an irregular temporal distribution and may indicate the involvement of an agent that exhibits epidemicity. We tested for the presence and nature of temporal clustering using population-based data from northern England. We extracted all cases of neuroblastic tumours diagnosed in children and young adults aged 0-24 years during 1968-2011 from the Northern Region Young Persons' Malignant Disease Registry. This is a population-based registry, covering a population of approximately 900,000 young persons, and includes all cases resident in northern England at the time of diagnosis. Tests for temporal clustering were applied using a modified version of the Potthoff-Whittinghill method. Estimates of extra-Poisson variation ([Formula: see text]) and standard errors (SEs) were obtained. 227 cases of neuroblastic tumours were diagnosed during the study period. All the analyses between fortnights and between months found significant extra-Poisson variation, with [Formula: see text] =0.846 (SE = 0.310, P = 0.004) for the analysis between fortnights within months. Restricting the analyses to the 76 cases diagnosed at ages less than 18 months showed significant extra-Poisson variation between fortnights within months ([Formula: see text] =1.532, SE = 0.866, P = 0.038), but not between months. In contrast, analyses of cases aged 18 months to 24 years showed significant extra-Poisson variation between quarters within years, as well as over shorter timescales. Transient environmental agents may be involved in the aetiology of neuroblastic tumours. The initiating factor might be a geographically-widespread agent that occurs in 'mini-epidemics'.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 21%
Researcher 2 14%
Student > Doctoral Student 1 7%
Student > Bachelor 1 7%
Student > Ph. D. Student 1 7%
Other 3 21%
Unknown 3 21%
Readers by discipline Count As %
Medicine and Dentistry 6 43%
Immunology and Microbiology 1 7%
Environmental Science 1 7%
Neuroscience 1 7%
Engineering 1 7%
Other 0 0%
Unknown 4 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 65. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2016.
All research outputs
#553,855
of 22,826,360 outputs
Outputs from Environmental Health
#146
of 1,489 outputs
Outputs of similar age
#8,071
of 267,016 outputs
Outputs of similar age from Environmental Health
#2
of 22 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,489 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.3. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,016 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.