Title |
Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness
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Published in |
Breast Cancer Research, October 2011
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DOI | 10.1186/bcr3049 |
Pubmed ID | |
Authors |
Esther H Lips, Nadja Laddach, Suvi P Savola, Marieke A Vollebergh, Anne MM Oonk, Alex LT Imholz, Lodewyk FA Wessels, Jelle Wesseling, Petra M Nederlof, Sjoerd Rodenhuis |
Abstract |
Our group has previously employed array Comparative Genomic Hybridization (aCGH) to assess the genomic patterns of BRCA1-mutated breast cancers. We have shown that the so-called BRCA1-like(aCGH) profile is also present in about half of all triple-negative sporadic breast cancers and is predictive for benefit from intensified alkylating chemotherapy. As aCGH is a rather complex method, we translated the BRCA1(aCGH) profile to a Multiplex Ligation-dependent Probe Amplification (MLPA) assay, to identify both BRCA1-mutated breast cancers and sporadic cases with a BRCA1-like(aCGH) profile. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | <1% |
Netherlands | 1 | <1% |
Germany | 1 | <1% |
Belgium | 1 | <1% |
Unknown | 100 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 24 | 23% |
Student > Ph. D. Student | 17 | 16% |
Student > Master | 14 | 13% |
Other | 9 | 9% |
Student > Bachelor | 8 | 8% |
Other | 12 | 12% |
Unknown | 20 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 24% |
Biochemistry, Genetics and Molecular Biology | 22 | 21% |
Agricultural and Biological Sciences | 20 | 19% |
Computer Science | 2 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 10 | 10% |
Unknown | 23 | 22% |