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Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness

Overview of attention for article published in Breast Cancer Research, October 2011
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Title
Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness
Published in
Breast Cancer Research, October 2011
DOI 10.1186/bcr3049
Pubmed ID
Authors

Esther H Lips, Nadja Laddach, Suvi P Savola, Marieke A Vollebergh, Anne MM Oonk, Alex LT Imholz, Lodewyk FA Wessels, Jelle Wesseling, Petra M Nederlof, Sjoerd Rodenhuis

Abstract

Our group has previously employed array Comparative Genomic Hybridization (aCGH) to assess the genomic patterns of BRCA1-mutated breast cancers. We have shown that the so-called BRCA1-like(aCGH) profile is also present in about half of all triple-negative sporadic breast cancers and is predictive for benefit from intensified alkylating chemotherapy. As aCGH is a rather complex method, we translated the BRCA1(aCGH) profile to a Multiplex Ligation-dependent Probe Amplification (MLPA) assay, to identify both BRCA1-mutated breast cancers and sporadic cases with a BRCA1-like(aCGH) profile.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Netherlands 1 <1%
Germany 1 <1%
Belgium 1 <1%
Unknown 100 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 24 23%
Student > Ph. D. Student 17 16%
Student > Master 14 13%
Other 9 9%
Student > Bachelor 8 8%
Other 12 12%
Unknown 20 19%
Readers by discipline Count As %
Medicine and Dentistry 25 24%
Biochemistry, Genetics and Molecular Biology 22 21%
Agricultural and Biological Sciences 20 19%
Computer Science 2 2%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 10 10%
Unknown 23 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2011.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Breast Cancer Research
#1,535
of 2,053 outputs
Outputs of similar age
#105,828
of 152,459 outputs
Outputs of similar age from Breast Cancer Research
#33
of 46 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 152,459 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.