Title |
Streptococcus pyogenes-purpura fulminans as an invasive form of group A streptococcal infection
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Published in |
Annals of Clinical Microbiology and Antimicrobials, July 2018
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DOI | 10.1186/s12941-018-0282-9 |
Pubmed ID | |
Authors |
Sayaka Okuzono, Masataka Ishimura, Shunsuke Kanno, Motoshi Sonoda, Noriyuki Kaku, Yoshitomo Motomura, Hisanori Nishio, Utako Oba, Masuo Hanada, Jun-ichi Fukushi, Michiyo Urata, Dongchon Kang, Hidetoshi Takada, Shouichi Ohga |
Abstract |
Streptococcus pyogenes is an uncommon pathogen of purpura fulminans, and the pathogenesis of S. pyogenes-purpura fulminans remains unclear because of paucity of cases. We reported a pediatric case of S. pyogenes-purpura fulminans with literature review of the disease. A 3-year-old boy showed limping, lethargy and acral gangrene within 24 h. A diagnosis of S. pyogenes-purpura fulminans was made for bacterial isolation from throat and peripheral blood. Intensive therapy led to a survival with amputation of the left distal metatarsal bone, and normal development. The isolated M12 carried no mutation of csrS/R or rgg. Thrombophilia or immunodeficiency was excluded. Twelve-reported cases (9 pediatric and 3 elderly) of S. pyogenes-purpura fulminans started with shock and coagulopathy. Five patients age < 8 years had no underlying disease and survived. One youngest and two immunocompromised patients died. Streptococcus pyogenes-acute infectious purpura fulminans is a distinctive rare form of aggressive GAS infections. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Venezuela, Bolivarian Republic of | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 6 | 15% |
Researcher | 5 | 13% |
Student > Master | 4 | 10% |
Student > Doctoral Student | 3 | 8% |
Student > Ph. D. Student | 2 | 5% |
Other | 5 | 13% |
Unknown | 15 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 28% |
Immunology and Microbiology | 4 | 10% |
Nursing and Health Professions | 2 | 5% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Business, Management and Accounting | 1 | 3% |
Other | 4 | 10% |
Unknown | 16 | 40% |