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Mendeley readers
| Title |
Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
|
|---|---|
| Published in |
Journal of Hematology & Oncology, July 2018
|
| DOI | 10.1186/s13045-018-0636-y |
| Pubmed ID | |
| Authors |
Ling Xu, Danlin Yao, Jiaxiong Tan, Zifan He, Zhi Yu, Jie Chen, Gengxin Luo, Chunli Wang, Fenfang Zhou, Xianfeng Zha, Shaohua Chen, Yangqiu Li |
| Abstract |
Stem cell memory T (TSCM) and central memory T (TCM) cells can rapidly differentiate into effector memory (TEM) and terminal effector (TEF) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of TSCM and TCM cells in the CD8+ population dramatically decreased together with increases in TEM and TEF cells, particularly in younger patients with acute myeloid leukemia (AML) (< 60 years). These alterations persisted in patients who achieved complete remission after chemotherapy. The decrease in TSCM and TCM together with the increase in differentiated TEM and TEF subsets in CD8+ T cells may explain the reduced T cell response and subdued anti-leukemia capacity in AML patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 22% |
| Student > Bachelor | 4 | 15% |
| Other | 3 | 11% |
| Student > Ph. D. Student | 1 | 4% |
| Lecturer | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 12 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 19% |
| Immunology and Microbiology | 4 | 15% |
| Biochemistry, Genetics and Molecular Biology | 4 | 15% |
| Energy | 1 | 4% |
| Chemistry | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 12 | 44% |