Title |
Proton pump inhibitors for the treatment of cancer in companion animals
|
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Published in |
Journal of Experimental & Clinical Cancer Research, September 2015
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DOI | 10.1186/s13046-015-0204-z |
Pubmed ID | |
Authors |
Megan Walsh, Stefano Fais, Enrico Pierluigi Spugnini, Salvador Harguindey, Tareq Abu Izneid, Licia Scacco, Paula Williams, Cinzia Allegrucci, Cyril Rauch, Ziad Omran |
Abstract |
The treatment of cancer presents a clinical challenge both in human and veterinary medicine. Chemotherapy protocols require the use of toxic drugs that are not always specific, do not selectively target cancerous cells thus resulting in many side effects. A recent therapeutic approach takes advantage of the altered acidity of the tumour microenvironment by using proton pump inhibitors (PPIs) to block the hydrogen transport out of the cell. The alteration of the extracellular pH kills tumour cells, reverses drug resistance, and reduces cancer metastasis. Human clinical trials have prompted to consider this as a viable and safe option for the treatment of cancer in companion animals. Preliminary animal studies suggest that the same positive outcome could be achievable. The purpose of this review is to support investigations into the use of PPIs for cancer treatment cancer in companion animals by considering the evidence available in both human and veterinary medicine. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 59 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 9 | 15% |
Student > Master | 8 | 14% |
Researcher | 8 | 14% |
Other | 8 | 14% |
Student > Ph. D. Student | 6 | 10% |
Other | 11 | 19% |
Unknown | 9 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 24% |
Biochemistry, Genetics and Molecular Biology | 10 | 17% |
Veterinary Science and Veterinary Medicine | 5 | 8% |
Chemistry | 5 | 8% |
Agricultural and Biological Sciences | 4 | 7% |
Other | 10 | 17% |
Unknown | 11 | 19% |