Title |
Immunogenicity of panitumumab in combination chemotherapy clinical trials
|
---|---|
Published in |
BMC Clinical Pharmacology, November 2011
|
DOI | 10.1186/1472-6904-11-17 |
Pubmed ID | |
Authors |
Dohan Weeraratne, Alin Chen, Jason J Pennucci, Chi-Yuan Wu, Kathy Zhang, Jacqueline Wright, Juan José Pérez-Ruixo, Bing-Bing Yang, Arunan Kaliyaperumal, Shalini Gupta, Steven J Swanson, Narendra Chirmule, Marta Starcevic |
Abstract |
Panitumumab is a fully human antibody against the epidermal growth factor receptor that is indicated for the treatment of metastatic colorectal cancer (mCRC) after disease progression on standard chemotherapy. The purpose of this analysis was to examine the immunogenicity of panitumumab and to evaluate the effect of anti-panitumumab antibodies on pharmacokinetic and safety profiles in patients with mCRC receiving panitumumab in combination with oxaliplatin- or irinotecan-based chemotherapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Hungary | 1 | 2% |
Unknown | 47 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 27% |
Student > Bachelor | 5 | 10% |
Student > Master | 5 | 10% |
Other | 3 | 6% |
Student > Ph. D. Student | 3 | 6% |
Other | 6 | 13% |
Unknown | 13 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 14 | 29% |
Agricultural and Biological Sciences | 7 | 15% |
Immunology and Microbiology | 3 | 6% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 6 | 13% |
Unknown | 13 | 27% |