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Epidemiologic evidence for association between adverse environmental exposures in early life and epigenetic variation: a potential link to disease susceptibility?

Overview of attention for article published in Clinical Epigenetics, September 2015
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  • Average Attention Score compared to outputs of the same age and source

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1 Facebook page

Citations

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74 Dimensions

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130 Mendeley
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Title
Epidemiologic evidence for association between adverse environmental exposures in early life and epigenetic variation: a potential link to disease susceptibility?
Published in
Clinical Epigenetics, September 2015
DOI 10.1186/s13148-015-0130-0
Pubmed ID
Authors

Alexander Vaiserman

Abstract

A growing body of evidence suggests that the risk of development and progression of a variety of human chronic diseases depends on epigenetic modifications triggered by environmental cues during early life sensitive stages. Exposures to environmental factors such as adverse nutritional, psychological, and social conditions, as well as pollutants and substance abuse in early life, have been shown to be important determinants of epigenetic programming of chronic pathological conditions in human populations. Over the past years, it has become increasingly clear due to the epigenome-wide association studies (EWASs) that early life adverse environmental events may trigger widespread and persistent alterations in transcriptional profiling. Several candidate genes have been identified underlying these associations. In this context, DNA methylation is the most intensively studied epigenetic phenomenon. In this review, the clinical and epidemiological evidence for the role of epigenetic factors in mediating the link between early life experiences and long-term health outcomes are summarized.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Unknown 128 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 18%
Student > Master 20 15%
Researcher 16 12%
Student > Doctoral Student 12 9%
Student > Bachelor 8 6%
Other 26 20%
Unknown 25 19%
Readers by discipline Count As %
Medicine and Dentistry 27 21%
Agricultural and Biological Sciences 19 15%
Biochemistry, Genetics and Molecular Biology 11 8%
Psychology 10 8%
Pharmacology, Toxicology and Pharmaceutical Science 7 5%
Other 18 14%
Unknown 38 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2015.
All research outputs
#6,961,889
of 22,828,180 outputs
Outputs from Clinical Epigenetics
#493
of 1,256 outputs
Outputs of similar age
#82,661
of 267,781 outputs
Outputs of similar age from Clinical Epigenetics
#24
of 40 outputs
Altmetric has tracked 22,828,180 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,256 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,781 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.