Title |
Epidemiologic evidence for association between adverse environmental exposures in early life and epigenetic variation: a potential link to disease susceptibility?
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Published in |
Clinical Epigenetics, September 2015
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DOI | 10.1186/s13148-015-0130-0 |
Pubmed ID | |
Authors |
Alexander Vaiserman |
Abstract |
A growing body of evidence suggests that the risk of development and progression of a variety of human chronic diseases depends on epigenetic modifications triggered by environmental cues during early life sensitive stages. Exposures to environmental factors such as adverse nutritional, psychological, and social conditions, as well as pollutants and substance abuse in early life, have been shown to be important determinants of epigenetic programming of chronic pathological conditions in human populations. Over the past years, it has become increasingly clear due to the epigenome-wide association studies (EWASs) that early life adverse environmental events may trigger widespread and persistent alterations in transcriptional profiling. Several candidate genes have been identified underlying these associations. In this context, DNA methylation is the most intensively studied epigenetic phenomenon. In this review, the clinical and epidemiological evidence for the role of epigenetic factors in mediating the link between early life experiences and long-term health outcomes are summarized. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 20% |
France | 1 | 20% |
United States | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Scientists | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 2% |
Unknown | 128 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 18% |
Student > Master | 20 | 15% |
Researcher | 16 | 12% |
Student > Doctoral Student | 12 | 9% |
Student > Bachelor | 8 | 6% |
Other | 26 | 20% |
Unknown | 25 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 21% |
Agricultural and Biological Sciences | 19 | 15% |
Biochemistry, Genetics and Molecular Biology | 11 | 8% |
Psychology | 10 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
Other | 18 | 14% |
Unknown | 38 | 29% |