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Daily estimation of the severity of organ dysfunctions in critically ill children by using the PELOD-2 score

Overview of attention for article published in Critical Care, December 2015
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  • Above-average Attention Score compared to outputs of the same age (52nd percentile)

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Title
Daily estimation of the severity of organ dysfunctions in critically ill children by using the PELOD-2 score
Published in
Critical Care, December 2015
DOI 10.1186/s13054-015-1054-y
Pubmed ID
Authors

Stéphane Leteurtre, Alain Duhamel, Valérie Deken, Jacques Lacroix, Francis Leclerc

Abstract

Daily or serial evaluation of multiple organ dysfunction syndrome (MODS) scores may provide useful information. We aimed to validate the daily (d) PELOD-2 score using the set of seven days proposed with the previous version of the score. In all consecutive patients admitted to nine pediatric intensive care units (PICUs) we prospectively measured the dPELOD-2 score at day 1, 2, 5, 8, 12, 16, and 18. PICU mortality was used as the outcome dependent variable. The discriminant power of the dPELOD-2 scores was estimated using the area under the ROC curve and the calibration using the Hosmer-Lemeshow chi-square test. We used a logistic regression to investigate the relationship between the dPELOD-2 scores and outcome, and between the change in PELOD-2 score from day1 and outcome. We included 3669 patients (median age 15.5 months, mortality rate 6.1 %, median length of PICU stay 3 days). Median dPELOD-2 scores were significantly higher in nonsurvivors than in survivors (p < 0.0001). The dPELOD-2 score was available at least at day 2 in 2057 patients: among the 796 patients without MODS on day1, 186 (23.3 %) acquired the syndrome during their PICU stay (mortality 4.9 % vs. 0.3 % among the 610 who did not; p < 0.0001). Among the1261 patients with MODS on day1, the syndrome worsened in 157 (12.4 %) and remained unchanged or improved in 1104 (87.6 %) (mortality 22.9 % vs. 6.6 %; p < 0.0001). The AUC of the dPELOD-2 scores ranged from 0.75 (95 % CI: 0.67-0.83) to 0.89 (95 % CI: 0.86-0.91). The calibration was good with a chi-square test between 13.5 (p = 0.06) and 0.9 (p = 0.99). The PELOD-2 score on day1 was a significant prognostic factor; the serial evaluation of the change in the dPELOD-2 score from day1, adjusted for baseline value, demonstrated a significant odds ratio of death for each of the 7 days. This study suggests that the progression of the severity of organ dysfunctions can be evaluated by measuring the dPELOD-2 score during a set of 7 days in PICU, providing useful information on outcome in critically ill children. Its external validation would be useful.

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Mendeley readers

Mendeley readers

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Geographical breakdown

Country Count As %
Canada 1 1%
Unknown 94 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 19 20%
Student > Bachelor 11 12%
Researcher 8 8%
Student > Doctoral Student 8 8%
Other 6 6%
Other 23 24%
Unknown 20 21%
Readers by discipline Count As %
Medicine and Dentistry 49 52%
Biochemistry, Genetics and Molecular Biology 5 5%
Engineering 4 4%
Nursing and Health Professions 3 3%
Unspecified 3 3%
Other 9 9%
Unknown 22 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2015.
All research outputs
#14,277,392
of 25,373,627 outputs
Outputs from Critical Care
#4,723
of 6,554 outputs
Outputs of similar age
#185,318
of 395,408 outputs
Outputs of similar age from Critical Care
#392
of 466 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,408 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 466 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.