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Flavonoids isolated from Tridax procumbens (TPF) inhibit osteoclasts differentiation and bone resorption

Overview of attention for article published in Biological Research, September 2015
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Title
Flavonoids isolated from Tridax procumbens (TPF) inhibit osteoclasts differentiation and bone resorption
Published in
Biological Research, September 2015
DOI 10.1186/s40659-015-0043-6
Pubmed ID
Authors

Md. Abdullah Al Mamun, Kamrul Islam, Md. Jahangir Alam, Amina Khatun, M. Masihul Alam, Md. Abdul Alim Al-Bari, Md. Jahangir Alam

Abstract

The Tridax procumbens flavonoids (TPF), are well known for their medicinal properties among local natives. The TPF are traditionally used for dropsy, anaemia, arthritis, gout, asthma, ulcer, piles, and urinary problems. It also used in treating gastric problems, body pain, and rheumatic pains of joints. The TPF have been reported to increase osteogenic functioning in mesenchymal stem cells. However, their effects on osteoclastogenesis remain unclear. The TPF isolated from T. procumbens and investigated the effects of the TPF inhibit on osteoclast differentiation and bone resorption activities using primary osteoclastic cells. Osteoclast formation was assessed by counting the number of tartrate resistant acid phosphatase (TRAP) positive multinucleated cells and by measuring both TRAP activities. The TPF significantly suppressed the RANKL-induced differentiation of osteoclasts and the formation of pits in primary osteoclastic cells. The TPF also decreased the expression of mRNAs related to osteoclast differentiation, including Trap, Cathepsin K, Mmp-9, and Mmp-13 in primary osteoclastic cells. The treatment of primary osteoclastic cells with the TPF decreased Cathepsin K, Mmp-9, and Mmp-13 proteins expression in primary osteoclastic cells. These results indicated that TPF inhibit osteoclastogenesis and pits formation activities. Our results suggest that the TPF could be a potential anti-bone resorptic agent to treat patients with bone loss-associated diseases such as osteoporosis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 23%
Student > Master 5 17%
Researcher 2 7%
Student > Postgraduate 2 7%
Student > Bachelor 2 7%
Other 5 17%
Unknown 7 23%
Readers by discipline Count As %
Medicine and Dentistry 7 23%
Pharmacology, Toxicology and Pharmaceutical Science 5 17%
Agricultural and Biological Sciences 4 13%
Biochemistry, Genetics and Molecular Biology 2 7%
Chemical Engineering 1 3%
Other 3 10%
Unknown 8 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2015.
All research outputs
#4,687,716
of 6,344,720 outputs
Outputs from Biological Research
#119
of 196 outputs
Outputs of similar age
#135,136
of 196,486 outputs
Outputs of similar age from Biological Research
#8
of 16 outputs
Altmetric has tracked 6,344,720 research outputs across all sources so far. This one is in the 14th percentile – i.e., 14% of other outputs scored the same or lower than it.
So far Altmetric has tracked 196 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,486 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.