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Normal tissue complication probability modeling for cochlea constraints to avoid causing tinnitus after head-and-neck intensity-modulated radiation therapy

Overview of attention for article published in Radiation Oncology, September 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)

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3 tweeters

Citations

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31 Dimensions

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63 Mendeley
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Title
Normal tissue complication probability modeling for cochlea constraints to avoid causing tinnitus after head-and-neck intensity-modulated radiation therapy
Published in
Radiation Oncology, September 2015
DOI 10.1186/s13014-015-0501-x
Pubmed ID
Authors

Tsair-Fwu Lee, Shyh-An Yeh, Pei-Ju Chao, Liyun Chang, Chien-Liang Chiu, Hui-Min Ting, Hung-Yu Wang, Yu-Jie Huang

Abstract

Radiation-induced tinnitus is a side effect of radiotherapy in the inner ear for cancers of the head and neck. Effective dose constraints for protecting the cochlea are under-reported. The aim of this study is to determine the cochlea dose limitation to avoid causing tinnitus after head-and-neck cancer (HNC) intensity-modulated radiation therapy (IMRT). In total 211 patients with HNC were included; the side effects of radiotherapy were investigated for 422 inner ears in the cohort. Forty-nine of the four hundred and twenty-two samples (11.6 %) developed grade 2+ tinnitus symptoms after IMRT, as diagnosed by a clinician. The Late Effects of Normal Tissues-Subjective, Objective, Management, Analytic (LENT-SOMA) criteria were used for tinnitus evaluation. The logistic and Lyman-Kutcher-Burman (LKB) normal tissue complication probability (NTCP) models were used for the analyses. The NTCP-fitted parameters were TD 50  = 46.31 Gy (95 % CI, 41.46-52.50), γ 50  = 1.27 (95 % CI, 1.02-1.55), and TD 50  = 46.52 Gy (95 % CI, 41.91-53.43), m = 0.35 (95 % CI, 0.30-0.42) for the logistic and LKB models, respectively. The suggested guideline TD 20 for the tolerance dose to produce a 20 % complication rate within a specific period of time was TD 20  = 33.62 Gy (95 % CI, 30.15-38.27) (logistic) and TD 20  = 32.82 Gy (95 % CI, 29.58-37.69) (LKB). To maintain the incidence of grade 2+ tinnitus toxicity <20 % in IMRT, we suggest that the mean dose to the cochlea should be <32 Gy. However, models should not be extrapolated to other patient populations without further verification and should first be confirmed before clinical implementation.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 63 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 21%
Student > Master 8 13%
Professor 4 6%
Other 4 6%
Student > Ph. D. Student 4 6%
Other 15 24%
Unknown 15 24%
Readers by discipline Count As %
Medicine and Dentistry 18 29%
Physics and Astronomy 8 13%
Nursing and Health Professions 6 10%
Psychology 2 3%
Engineering 2 3%
Other 6 10%
Unknown 21 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2020.
All research outputs
#9,557,987
of 16,562,219 outputs
Outputs from Radiation Oncology
#593
of 1,662 outputs
Outputs of similar age
#111,996
of 249,307 outputs
Outputs of similar age from Radiation Oncology
#1
of 1 outputs
Altmetric has tracked 16,562,219 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,662 research outputs from this source. They receive a mean Attention Score of 2.5. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,307 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them