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The association between maternal urinary phthalate concentrations and blood pressure in pregnancy: The HOME Study

Overview of attention for article published in Environmental Health, September 2015
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Title
The association between maternal urinary phthalate concentrations and blood pressure in pregnancy: The HOME Study
Published in
Environmental Health, September 2015
DOI 10.1186/s12940-015-0062-3
Pubmed ID
Authors

Erika F. Werner, Joseph M. Braun, Kimberly Yolton, Jane C. Khoury, Bruce P. Lanphear

Abstract

Exposure to phthalates, a class of endocrine disrupting chemicals, is ubiquitous. We examined the association of urinary phthalate metabolite concentrations during pregnancy with maternal blood pressure and risk of pregnancy-induced hypertensive diseases. We used data from the Health Outcomes and Measures of the Environment Study, a prospective birth cohort of low-risk pregnant women recruited between March 2003 and January 2006. We analyzed maternal urine samples collected at 16 and 26 weeks gestation for 9 phthalate monoester metabolites reflecting exposure to 6 phthalate diesters. Outcomes included maternal blood pressure at <20 and ≥20 weeks gestation and pregnancy induced hypertensive diseases (gestational hypertension, preeclampsia, eclampsia, and HELLP syndrome). Data were available for 369 women who gave birth to singleton, live-born infants without congenital anomalies. Of the phthalate metabolites evaluated, only mono-benzyl phthalate (MBzP) concentrations were significantly associated with maternal diastolic blood pressure at <20 weeks gestation. Women in the third MBzP tercile at 16 weeks gestation had diastolic blood pressure 2.2 (95 % CI: 0.5-3.9) mm Hg higher at <20 weeks gestation and 2.8 (95 % CI: 0.9-4.7) mm Hg higher at ≥20 weeks gestation compared to women in the first tercile. Compared to women in the first tercile, women in the top MBzP tercile at 16 weeks had an increased risk of developing pregnancy-induced hypertensive diseases (RR = 2.92, 95 % CI 1.15-7.41, p-value for trend = 0.01). MBzP concentrations at 26 weeks gestation were not as strongly associated with blood pressure at ≥20 weeks gestation or risk of pregnancy-induced hypertensive diseases. This study suggests that maternal urinary MBzP concentrations may be associated with increased diastolic blood pressure and risk of pregnancy-induced hypertensive diseases.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Portugal 1 1%
Unknown 87 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 18%
Student > Ph. D. Student 11 12%
Student > Bachelor 11 12%
Student > Doctoral Student 6 7%
Student > Master 6 7%
Other 12 13%
Unknown 27 30%
Readers by discipline Count As %
Medicine and Dentistry 14 16%
Agricultural and Biological Sciences 9 10%
Biochemistry, Genetics and Molecular Biology 7 8%
Nursing and Health Professions 6 7%
Environmental Science 6 7%
Other 9 10%
Unknown 38 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2022.
All research outputs
#7,007,001
of 24,393,299 outputs
Outputs from Environmental Health
#818
of 1,559 outputs
Outputs of similar age
#80,144
of 277,296 outputs
Outputs of similar age from Environmental Health
#12
of 22 outputs
Altmetric has tracked 24,393,299 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,559 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.9. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,296 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.