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Mendeley readers
Attention Score in Context
| Title |
Transcriptional network analysis on brains reveals a potential regulatory role of PPP1R3F in autism spectrum disorders
|
|---|---|
| Published in |
BMC Research Notes, July 2018
|
| DOI | 10.1186/s13104-018-3594-0 |
| Pubmed ID | |
| Authors |
Abolfazl Doostparast Torshizi, Jubao Duan, Kai Wang |
| Abstract |
This study aims at identifying master regulators of transcriptional networks in autism spectrum disorders (ASDs). With two sets of independent RNA-Seq data generated on cerebellum from patients with ASDs and control subjects (N = 39 and 45 for set 1, N = 24 and 38 for set 2, respectively), we carried out a network deconvolution of transcriptomic data, followed by virtual protein activity analysis. We identified PPP1R3F (Protein Phosphatase 1 Regulatory Subunit 3F) as a candidate master regulator affecting a large body of downstream genes that are associated with the disease phenotype. Pathway analysis on the identified targets of PPP1R3F in both datasets indicated alteration of endocytosis pathway. Despite a limited sample size, our study represents one of the first applications of network deconvolution approach to brain transcriptomic data to generate hypotheses that may be further validated by large-scale studies. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 21% |
| Student > Master | 5 | 18% |
| Student > Ph. D. Student | 2 | 7% |
| Professor > Associate Professor | 2 | 7% |
| Unspecified | 2 | 7% |
| Other | 3 | 11% |
| Unknown | 8 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 5 | 18% |
| Biochemistry, Genetics and Molecular Biology | 3 | 11% |
| Computer Science | 3 | 11% |
| Unspecified | 2 | 7% |
| Arts and Humanities | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 12 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2019.
All research outputs
#14,421,028
of 23,096,849 outputs
Outputs from BMC Research Notes
#1,979
of 4,287 outputs
Outputs of similar age
#168,449
of 296,625 outputs
Outputs of similar age from BMC Research Notes
#55
of 152 outputs
Altmetric has tracked 23,096,849 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,287 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,625 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 152 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.